Identifying cardiac amyloidosis in older adults with lumbar spinal stenosis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to identify older adults who have undergone lumbar spinal stenosis surgery and may have transthyretin cardiac amyloidosis (ATTR-CA). By analyzing spinal specimens for amyloid deposits, the study seeks to evaluate the prevalence of ATTR-CA and explore the use of artificial intelligence in identifying amyloid histologically. Participants will undergo various diagnostic tests, including nuclear scintigraphy and echocardiograms, to assess the presence of clinical manifestations of ATTR-CA. The study will be conducted at multiple prestigious medical centers, with a focus on early identification of this condition to facilitate timely treatment.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Clinically indicated spinal decompressive surgery within 20 years prior to enrollment.
2. Age ≥50 years at the time of the surgery.
3. Able to understand and sign the informed consent document after the nature of the study has been fully explained.

Exclusion Criteria:

The presence of any of the following excludes eligibility for enrollment in this study:

1. Confirmed primary amyloidosis (AL) or secondary amyloidosis (AA).
2. Known TTR amyloidosis.
3. Other reason that would make the subject inappropriate for entry into this study.

Where it's running

• Cedars-Sinai Medical Center
  Beverly Hills, California, United States Recruiting
• Tufts Medical Center
  Boston, Massachusetts, United States Recruiting
• Boston Medical Center
  Boston, Massachusetts, United States Recruiting
• Columbia University Irving Medical Center
  New York, New York, United States Recruiting
• Cleveland Clinic
  Cleveland, Ohio, United States Recruiting
• Mayo Clinic
  Rochester, Minnesota, United States Active not recruiting

Study contacts

• Principal investigator: Mathew S Maurer, MD — Columbia University
• Study coordinator: Mathew S Maurer, MD
• Email: msm10@cumc.columbia.edu
• Phone: 212-932-4537

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Diagnosing ATTR Cardiac Amyloidosis in Patients with Carpal Tunnel Syndrome

  This study is testing if patients with carpal tunnel syndrome might also have a heart condition called ATTR amyloidosis by doing tests and following them for 10 years.

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• Liver and Coagulation Markers in ATTR Cardiac Amyloidosis

  This study tests liver function and blood-clotting markers in people with ATTR-CA to see if they reflect disease severity and progression.

  Recruiting University of Messina · Messina, Sicily · NCT07766135

• Microdecompression alone vs. decompression with fusion in adjacent segment stenosis

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  Recruiting Charite University, Berlin, Germany · Berlin, State of Berlin · NCT07661199

• Cardiac Amyloidosis: See if Intracardiac Thrombi are Common on CT

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  Recruiting Centre Hospitalier Universitaire Dijon · Dijon · NCT07648303

• Comparison of two TLIF procedures for single-level lumbar spinal stenosis

  This trial tests two minimally invasive TLIF procedures (LUSE-TLIF and MIS-TLIF) to see which better helps people with single-level lumbar spinal stenosis who have not improved with non-surgical treatments.

  Recruiting The Third Affiliated Hospital of Southern Medical University · Guangzhou, Guangdong · NCT07588555

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.