Predicting anxiety and memory using brain and body signals

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to develop the CAMERA platform, which utilizes multimodal sensor data to predict anxiety and memory states in patients with Temporal Lobe Epilepsy undergoing inpatient monitoring. By recording neural, physiological, behavioral, and environmental signals, CAMERA seeks to provide a continuous and high-resolution assessment of anxiety and cognitive performance. The platform incorporates context-aware assessments that adapt based on the patient's physiology and behavior, enhancing the accuracy of predictions. This innovative approach addresses the limitations of current behavioral measurement methods, allowing for a more comprehensive understanding of the relationships between brain activity, anxiety, and memory.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients must have known or suspected Temporal Lobe Epilepsy.
* Native or proficient in speaking English or Spanish.
* Stereoelectroencephalography (sEEG) cases: The implant plan must include hippocampal head, body, and tail electrodes either unilaterally or bilaterally.
* 7th grade reading level (minimum level considered literate for adults)

Exclusion Criteria:

* Hearing impaired (i.e., not corrected with a hearing aid)
* Unable to read the newspaper at arm's length with corrective lenses.
* Objective intellectual impairment (estimated IQ \< 70)
* Any history of Electroconvulsive Therapy or psychosis (except postictal psychosis for patients)
* Psychotic disorder (lifetime)
* Current Anxiety disorder, Major Depressive Disorder, or Bipolar Disorder
* Neurodegenerative diseases, presence of widespread brain lesions, language problems (other than naming difficulty)
* Medical conditions that could potentially affect cognitive performance (e.g., human immunodeficiency virus (HIV) infection, cancer with metastatic potential).
* Acute renal failure or end-stage renal disease

Where it's running

• Columbia University Irving Medical Center
  New York, New York, United States Recruiting

Study contacts

• Principal investigator: Brett E Youngerman, MD — Columbia University
• Study coordinator: Brett E Youngerman, MD
• Email: bey2103@cumc.columbia.edu
• Phone: 516-946-2145

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.