Effects of atorvastatin on inflammation in sleep apnea patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study aims to evaluate whether a daily dose of atorvastatin can reduce inflammatory markers in patients with obstructive sleep apnea (OSA) who are being treated with continuous positive airway pressure (CPAP). The study employs a double-blind, placebo-controlled design over a period of four weeks, focusing on two main objectives: the impact of statins on endothelial inflammation and pro-thrombotic conditions, and their effect on endothelial cholesterol metabolism in OSA patients. By investigating these factors, the study seeks to provide insights into potential cardiovascular risk reduction strategies for individuals with OSA.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Aged ≥18 years
* Newly diagnosed with obstructive sleep apnea (OSA) who were never treated with CPAP. OSA is defined as apnea-hypopnea index (AHI) ≥5 events/hour of sleep.

Exclusion Criteria:

* A history of coronary artery disease, heart failure, stroke, diabetes, malignancy, chronic pulmonary, kidney or rheumatologic disease, muscle pain/fatigue, smoking within the past 5 years
* Regular use of any medications

Where it's running

• Columbia University Irving Medical Center
  New York, New York, United States Recruiting

Study contacts

• Principal investigator: Sanja Jelic, MD — Columbia University
• Study coordinator: Sanja Jelic, MD
• Email: sj366@cumc.columbia.edu
• Phone: 2125438875

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Training to strengthen breathing muscles in people with obstructive sleep apnea

  This study is testing if a special breathing exercise program can help adults with obstructive sleep apnea feel less sleepy during the day and improve their breathing at night while using CPAP.

  Recruiting Centre Hospitalier Régional d'Orléans · Orléans · NCT06117579

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.