Impact of home-based walking on cognitive function in older adults with kidney disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to determine whether a 6-month home-based walking program can enhance memory and brain structure and function in older adults suffering from chronic kidney disease and mild cognitive impairment. Participants will undergo initial assessments of heart health, physical function, and cognitive abilities, followed by randomization into either the walking program or a health education group. Throughout the intervention, participants will receive a fitness tracker and ongoing telephone coaching to support their exercise regimen. After 6 months, participants will be reassessed to evaluate the effects of the intervention.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* • Diagnosed stage 3-4 chronic kidney disease (CKD, estimated glomerular filtration rate (eGFR) \<60 to 20 ml/min);

  * \>55 yrs of age
  * Mild cognitive impairment (18-26 on the MOCA)
  * ability to undergo an MR
  * no history of major head trauma (No head trauma/concussion with loss of consciousness)
  * Speaks, reads, writes English

Exclusion Criteria:

* • Diagnosed Dementia or a Clinical Dementia Rating Scale score of \<2, or a MOCA of \<18

  * Participating in a supervised exercise program with intent to increase fitness levels 3 days/week,
  * Requires assistive ambulation
  * Limited exercise capacity due to claudication; unstable angina, severe arthritis, extreme dyspnea on exertion, unstable coronary artery disease
  * Class III-IV heart failure
  * History of uncontrolled sustained arrhythmias, severe/symptomatic aortic or mitral stenosis, hypertrophic obstructive cardiomyopathy, severe pulmonary hypertension, active myocarditis/pericarditis, thrombophlebitis, and recent systemic/pulmonary embolus
  * Resting systolic BP \>200 mmHg or resting diastolic BP \>110 mmHg
  * Any unforeseen illness or disability that would preclude cognitive testing or exercise training
  * One or more contraindication for MRI; cardiac pacemaker, aneurysm clip, cochlear implants, shrapnel, history of metal fragments in eyes, neurostimulators, diagnosed claustrophobia (MRI only)
  * Any self-reported major psychiatric disorders requiring medical therapy (e.g. schizophrenia, bipolar disorder).
  * Self-reported new diagnosis of clinical depression within 3 months of enrollment or unstable clinical depression requiring medication adjustment within 3 months of enrollment

Where it's running

• Georgetown University
  Washington D.C., District of Columbia, United States Recruiting
• Columbia University
  New York, New York, United States Recruiting

Study contacts

• Principal investigator: Shayan Shirazian, MD — Columbia University
• Study coordinator: Ulf G Bronas, PhD
• Email: ub2154@cumc.columbia.edu
• Phone: 212-305-0750

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.