Using radiofrequency ablation to treat indeterminate thyroid nodules
Official title: Radiofrequency Ablation for Indeterminate Bethesda III Thyroid Nodules
Run by Columbia University · NCT05189808 · Data updated 2026-11-12
This study is testing whether using radiofrequency ablation can safely treat certain thyroid nodules without the need for surgery.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 50 (estimated) |
| Sponsor | Columbia University Academic / other |
| Locations | 1 site (New York, New York) |
| Status | Recruiting |
| Started | August 1, 2020 |
| Main results expected | August 2027 |
| Study ends | August 2028 |
| Registry record updated | May 29, 2026 |
| Trial ID | NCT05189808 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are patients with indeterminate Bethesda III thyroid nodules that have been molecularly profiled as benign.
✕Probably not a fit
Patients with cardiac arrhythmias or those who are pregnant will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study evaluates the efficacy and safety of radiofrequency ablation (RFA) for treating indeterminate Bethesda III thyroid nodules. It involves a chart review where patient data is collected before and after the RFA procedure, which uses image guidance to deliver high-frequency electrical currents to the nodules, generating heat to treat them. The study aims to provide insights into the outcomes of RFA, potentially reducing unnecessary surgeries for patients with benign nodules.
Why it matters
Potential benefit: If successful, this approach could reduce the need for surgical interventions in patients with indeterminate thyroid nodules, minimizing risks and complications.
How similar studies have gone: Other studies have shown promising results with radiofrequency ablation for thyroid nodules, indicating that this approach is gaining traction in clinical practice.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Indeterminate Bethesda III nodules that have been molecularly profiled benign with either Afirma Genomic Sequencing Classifier (GSC) or ThyroSeq v3 tests Exclusion Criteria: * cardiac arrthymias * pregnancy
Where it's running
-
Columbia University
New York, New York, United States Recruiting
Study contacts
- Principal investigator: Jennifer H Kuo, MD MS — Columbia University
- Study coordinator: Jennifer H Kuo, MD MS
- Email: jhk2029@cumc.columbia.edu
- Phone: 212-305-6969
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.