Post-Vasectomy Pain Management Aftercare
Official title: A Randomized Controlled Trial of Post-vasectomy Pain Management
Run by Columbia University · NCT07824258 · Data updated 2026-11-12
This study tests four pain-control regimens after vasectomy to see which helps men feel better and how much pain relief they get.
Quick facts
| Phase | Phase 1 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years to 65 Years |
| Sex | Men only |
| Enrollment | 200 (estimated) |
| Sponsor | Columbia University Academic / other |
| Locations | 2 sites (New York, New York and 1 other locations) |
| Status | Recruiting |
| Started | September 10, 2026 |
| Main results expected | December 31, 2030 |
| Study ends | December 31, 2035 |
| Registry record updated | September 24, 2026 |
| Trial ID | NCT07824258 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adult men planning to have a vasectomy at participating centers who do not have kidney or liver disease, chronic pain, or a history of drug abuse.
✕Probably not a fit
Patients with specific contraindications to NSAIDs or opioids, or those who do not experience pain post-operatively, may see little to no benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a four-arm, unblinded randomized trial comparing common post-vasectomy pain regimens. Participants are adult men undergoing vasectomy at Columbia University Medical Center who do not have kidney or liver disease, chronic pain, or a history of drug abuse. Arms vary in acetaminophen alone, acetaminophen with ibuprofen, and the possible addition of oxycodone, with or without NSAIDs, over the first 48 hours and up to seven days. Outcomes include pain scores, opioid use, and return-to-work status, assessed via brief pain inventories and follow-up visits.
Why it matters
Potential benefit: If successful, the regimen that provides better pain control with acceptable safety could reduce post-vasectomy discomfort and opioid exposure.
How similar studies have gone: Prior studies have explored individual pain regimens, but this trial uniquely compares four regimens head-to-head in a vasectomy setting.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: \- Consent for vasectomy Exclusion Criteria: * History of kidney or liver disease * History of chronic pain condition * History of drug abuse
Where it's running
-
Columbia University Medical Center/ New York Presbyterian Hospital
New York, New York, United States Recruiting -
New York-Presbyterian The One
White Plains, New York, United States Recruiting
Study contacts
- Principal investigator: Aaron Brant, MD — Columbia University
- Study coordinator: Aaron Brant, MD
- Email: menshealth@cumc.columbia.edu
- Phone: 212-305-0114
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.