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Clinical trials and research at Baylor College of Medicine

• 100Clinical trials
• 1254NIH research projects
• 4Countries

Newest trials

All recruiting trials (100)

• GelPOINT Path-assisted endoscopic removal of colorectal polyps

  This study tests whether using the GelPOINT Path access platform during endoscopic submucosal dissection can safely help remove colorectal polyps in adults.

  Recruiting Baylor College of Medicine · Houston, Texas · NCT07723937

• Acceptance Based Coping Skills for Hispanic/Latino Military Patients With Type 2 Diabetes

  A bilingual health coach will lead a 10-week telehealth program to help Hispanic/Latino military patients with type 2 diabetes manage their condition better.

  Recruiting Baylor College of Medicine · San Antonio, Texas · NCT07674628

• Postoperative Pain After Pediatric Adenotonsillectomy: Ibuprofen Plus Tylenol vs Ketorolac Plus Tylenol

  This observational study will see if teens (13-18) who have adenotonsillectomy and take acetaminophen with ibuprofen or acetaminophen with ketorolac after discharge experience different levels of pain and recovery.

  Recruiting Baylor College of Medicine · Houston, Texas · NCT07672418

• Non-invasive brain stimulation to try to improve memory in early Alzheimer's

  Scientists test whether repetitive transcranial magnetic stimulation to the cerebellum can help short-term memory in people with early Alzheimer's disease compared with a sham procedure.

  Recruiting Baylor College of Medicine · Houston, Texas · NCT07667478

• Using a steroid cream to prevent repeat urinary tract infections in uncircumcised baby boys

  This pilot will test whether applying a steroid cream twice weekly for four weeks can help prevent repeat urinary tract infections in uncircumcised male infants under 6 months who have had a first UTI.

  Recruiting Phase 4 Baylor College of Medicine · Houston, Texas and 2 other locations · NCT07508124

• Speedboat UltraSlim™ for POEM in adults with achalasia and other esophageal motility disorders.

  This registry will see if using the Speedboat UltraSlim™ device for POEM is safe and effective for adults with achalasia or other esophageal motility disorders.

  Recruiting Baylor College of Medicine · Houston, Texas · NCT07496840

• Reducing unnecessary antibiotics for urinary tract infections by improving urine collection

  This study will test whether a bilingual (English and Spanish) animated video and pictorial flyer can help adults in safety‑net primary care give cleaner urine samples to reduce contaminated cultures and unnecessary antibiotic prescriptions.

  Recruiting Baylor College of Medicine · Houston, Texas · NCT07246837

• Registry for relapsed or progressive SHH medulloblastoma with U1 mutation

  This registry collects medical records and biological samples from people aged 3–50 with relapsed or progressive SHH medulloblastoma to test for U1 mutations and create a biobank for research.

  Recruiting at 2 sites Baylor College of Medicine · Houston, Texas and 1 other locations · NCT07242963

• Stepped care program for anxiety in children and teens

  This program will see if a stepped care approach that starts with parent-focused support and steps up to child therapy can help children and teens (ages 7–17) in Texas with anxiety disorders or OCD.

  Recruiting Baylor College of Medicine · Houston, Texas · NCT07228143

• Physician-modified endograft repair for complex abdominal and thoracoabdominal aortic aneurysms in high-risk patients

  This study will try physician-modified endografts to repair complex abdominal and thoracoabdominal aortic aneurysms in patients who are too high-risk for open surgery and do not meet criteria for currently approved devices.

  Recruiting Baylor College of Medicine · Houston, Texas · NCT07224230

• Guided imagery therapy app for kids with functional abdominal pain

  This study tests a guided imagery therapy app to see if it helps school-age children with functional abdominal pain disorders.

  Recruiting at 2 sites Baylor College of Medicine · Austin, Texas and 1 other locations · NCT07222943

• CD7 CAR T therapy for high-risk T-cell cancers

  This study tests a patient’s own edited T cells, engineered to target CD7, in people with relapsed or high-risk T-cell leukemia or lymphoma.

  Recruiting Phase 1 Baylor College of Medicine · Houston, Texas and 1 other locations · NCT07220993

• Kratom and other substances safety in people with past opioid use

  This study tests kratom at different doses against a placebo and oxycodone to see how people with a history of opioid use tolerate and respond to them.

  Recruiting Phase 1 Baylor College of Medicine · Houston, Texas · NCT07218549

• NKG2D.zeta-NK cells plus C7R.GD2.CAR-T cells for relapsed or refractory neuroblastoma or osteosarcoma

  This study tests a combination of modified NK cells and CAR-T cells to see if it can safely help patients with GD2-expressing relapsed or refractory neuroblastoma or osteosarcoma.

  Recruiting Phase 1 Baylor College of Medicine · Houston, Texas · NCT07211737

• Rapid genetic testing and virtual genetic consults for newborns with unexplained birth defects in Texas

  This project will test rapid whole genome sequencing and virtual genetic consultations for seriously ill newborns in Texas to find genetic causes of birth defects.

  Recruiting Baylor College of Medicine · Houston, Texas · NCT07102966

• Updated monitoring and treatment plan to improve outcomes for children and young adults with AML

  This trial will test replacing two standard chemotherapy cycles with Ida‑FLA and a venetoclax‑containing regimen for children and young adults (1 month–30 years) with intermediate‑ or high‑risk newly diagnosed AML to see if survival is as good or better with fewer long‑term complications.

  Recruiting Early Phase 1 Baylor College of Medicine · Houston, Texas · NCT07059975

• Mobile app for health behavior monitoring in Hispanic adolescents

  This study tests a mobile app that helps Hispanic teens who are overweight or obese track their weight, activity, sleep, and diet to see if it can help them live healthier lives.

  Recruiting Baylor College of Medicine · Houston, Texas · NCT06959901

• Intra-Arterial Magnesium Therapy After Mechanical Thrombectomy for Acute Ischemic Stroke

  This phase I study tests whether injecting magnesium sulfate directly into brain arteries after mechanical clot removal is safe for people with acute ischemic stroke.

  Recruiting Phase 1 Baylor College of Medicine · Houston, Texas · NCT06956521

• Telehealth program for preventing diabetes in Hispanic teens

  This study is testing a new online program to help Hispanic teens who are overweight prevent diabetes by making it easier for them and their families to join in.

  Recruiting Baylor College of Medicine · Houston, Texas · NCT06943001

• Healthy cooking and feeding skills for parents and their 3–5-year-olds

  This program tests whether an online cooking and feeding course, with or without a one-time home food delivery, helps parents of 3–5-year-olds cook healthier meals and involve their preschoolers.

  Recruiting Baylor College of Medicine · Houston, Texas · NCT06940817

• Evaluating treatment protocols for pediatric acute myeloid leukemia in Malawi

  This study is testing a new treatment plan for children with acute myeloid leukemia in Malawi to see if it can help them survive better and handle side effects more easily.

  Recruiting Baylor College of Medicine · Lilongwe, Lilongwe · NCT06928909

• Assessing the effects of psilocybin therapy on PTSD in veterans

  This study is testing whether psilocybin therapy can help U.S. military veterans with PTSD feel better and recover from their trauma.

  Recruiting Phase 2 Baylor College of Medicine · Houston, Texas · NCT06888128

• Evaluating uterine entry techniques for laser treatment in twin-to-twin transfusion syndrome

  This study is testing whether different ways to enter the uterus for laser treatment can improve outcomes for pregnant women with twin-to-twin transfusion syndrome.

  Recruiting Baylor College of Medicine · Houston, Texas · NCT06829901

• GPC3-targeted CAR T cell therapy for recurrent GPC3-positive glioblastoma

  This study will try CAR T cells engineered to target GPC3 in adults with recurrent GPC3-positive glioblastoma during their planned surgery.

  Recruiting Phase 1 Baylor College of Medicine · Houston, Texas · NCT06815432

• Development of a flexible 3D-printed scoliosis brace

  This study is testing a new 3D-printed scoliosis brace for kids and teens to see if it’s more comfortable and helps them stick to their treatment better.

  Recruiting Baylor College of Medicine · Houston, Texas and 1 other locations · NCT06785207

• Increasing exercise and stopping evening snacks to improve metabolic health in youth with prediabetes

  This study is testing if getting more exercise and stopping evening snacks can help teenagers with prediabetes improve their health.

  Recruiting Baylor College of Medicine · Houston, Texas · NCT06782906

• Genome sequencing for newborns with perinatal hypoxic‑ischemic encephalopathy

  This program will try genome sequencing for newborns with moderate-to-severe hypoxic‑ischemic encephalopathy who are receiving therapeutic cooling, using parent samples to help interpret results.

  Recruiting at 2 sites Baylor College of Medicine · Houston, Texas and 1 other locations · NCT06762795

• Combination of HPV Vaccine, Imiquimod, and Metformin for Cancer Treatment

  This study is testing if a combination of an HPV vaccine, a skin treatment called imiquimod, and a diabetes drug called metformin can help people with advanced cervical, vaginal, or vulvar cancer live longer without their cancer getting worse.

  Recruiting Phase 2 Baylor College of Medicine · Houston, Texas and 1 other locations · NCT06686043

• Effects of intrathecal baclofen on children with dystonic cerebral palsy

  This study is testing if a medication called intrathecal baclofen can help reduce muscle stiffness and improve movement in children with dystonic cerebral palsy.

  Recruiting Baylor College of Medicine · Houston, Texas · NCT06606574

• Deep Brain Stimulation for Severe Bipolar Depression

  This study is testing whether Deep Brain Stimulation can help people with severe bipolar depression who haven't found relief from other treatments.

  Recruiting Baylor College of Medicine · Boston, Massachusetts and 3 other locations · NCT06599099

• Investigating brain activity in patients with OCD using deep brain stimulation

  This study is testing how deep brain stimulation can help people with severe OCD by looking at their brain activity and behaviors in different settings.

  Recruiting at 2 sites Baylor College of Medicine · Houston, Texas and 1 other locations · NCT06596447

• Using a new bipolar knife for removing esophageal lesions

  This study is testing a new type of tool for safely removing esophageal growths in patients with precancerous lesions to see if it works better than older methods.

  Recruiting Baylor College of Medicine · Houston, Texas · NCT06476678

• Using Dronabinol to Help Reduce Chronic Low Back Pain

  This study is testing if a synthetic form of THC can help people with chronic low back pain feel better when used alongside their usual treatments.

  Recruiting Phase 2 Baylor College of Medicine · Houston, Texas · NCT06454669

• Using AI technology to improve esophageal cancer detection

  This study is testing if a new AI tool can help doctors find esophageal cancer more accurately in high-risk patients during routine screenings.

  Recruiting at 4 sites Phase 2 Baylor College of Medicine · Houston, Texas and 3 other locations · NCT06435286

• CD70-targeted CAR-T therapy for certain leukemias

  This trial tests a specially engineered T-cell therapy to see if it can help people with CD70-expressing leukemias that have come back or not responded to standard treatment.

  Recruiting at 2 sites Phase 1 Baylor College of Medicine · Houston, Texas and 1 other locations · NCT06345027

• Understanding genetic factors in children with eye defects

  This study is trying to learn more about the genetic factors and physical traits in children with eye defects like Microphthalmia, Anophthalmia, and Coloboma to improve prevention and treatment options.

  Recruiting Baylor College of Medicine · Houston, Texas · NCT06293560

• Exploring biomarkers in RAI1-related disorders

  This study is trying to find new markers in the blood and other tests that can help us understand and treat Smith-Magenis syndrome and Potocki-Lupski Syndrome better.

  Recruiting Baylor College of Medicine · Houston, Texas · NCT06274164

• Telehealth program to help teens with depression

  This study tests a telehealth program that helps teens aged 12-17 with depression by teaching them skills to engage in enjoyable activities over eight weeks.

  Recruiting Baylor College of Medicine · Houston, Texas · NCT06273995

• HTR2 CAR T Cells Targeting HER2 in Metastatic Breast Cancer

  A one-time treatment with specially modified T cells that target HER2-positive metastatic breast cancer is tested to see if it’s safe and how long the cells last, with a plan for possible dose increases.

  Recruiting Phase 1 Baylor College of Medicine · Houston, Texas · NCT06251544

• IL-15 and IL-21–armored GPC3-CAR T cell therapy for adults with GPC3-positive solid tumors

  This trial tests whether CAR T cells engineered to target GPC3 and fortified with IL-15 and IL-21 can treat adults with GPC3-positive liver and other solid tumors.

  Recruiting Phase 1 Baylor College of Medicine · Houston, Texas · NCT06198296

• Examining how evening light and media affect children's sleep and emotions

  This study is testing how different types of evening screen time, like bright or dim lights and calming or exciting shows, affect the sleep and emotions of kids aged 8 to 11.

  Recruiting Baylor College of Medicine · Houston, Texas · NCT06192745

• Banked C7R-modified allogeneic CD30-targeted CAR T cells for CD30-positive lymphomas

  This will try a donated (banked) C7R.CD30.CAR-EBVST cell infusion to treat people aged 12–75 whose CD30-positive lymphoma has returned or not responded to prior treatments.

  Recruiting Phase 1 Baylor College of Medicine · Houston, Texas and 1 other locations · NCT06176690

• Comparing traction and no traction in colonic endoscopic submucosal dissection

  This study is testing if using a traction device during a specific type of colon surgery can help patients have quicker and easier procedures compared to standard methods.

  Recruiting at 2 sites Baylor College of Medicine · Houston, Texas and 1 other locations · NCT06159634

• Using a new overtube to improve colonic endoscopic procedures

  This study is testing a new tool to see if it can make colon procedures easier and safer for patients with certain growths in their intestines.

  Recruiting at 2 sites Baylor College of Medicine · Houston, Texas and 1 other locations · NCT06134687

• Heart Coherence Training for Patients with Vascular Ehlers-Danlos Syndrome

  This study is testing an 8-week online program to see if heart coherence training can help people with Vascular Ehlers-Danlos Syndrome manage stress and anxiety better.

  Recruiting Baylor College of Medicine · Houston, Texas · NCT05994664

• Montelukast for cognitive and mood symptoms in Gulf War veterans

  This trial tests whether montelukast, an FDA-approved asthma medicine, can improve thinking, mood, and daily function in veterans with Gulf War Illness.

  Recruiting Phase 1 Baylor College of Medicine · Houston, Texas · NCT05992311

• Improving spinal cord stimulation for chronic pain relief

  This study is testing if a new type of spinal cord stimulation can help people with chronic pain feel better compared to the standard method.

  Recruiting Baylor College of Medicine · Houston, Texas · NCT05968664

• Combination of immunotherapy and chemotherapy for mesothelioma treatment

  This study is testing whether combining two immunotherapy drugs with chemotherapy can help people with a type of lung cancer called mesothelioma live longer without their cancer coming back.

  Recruiting Phase 1/2 Baylor College of Medicine · Durham, North Carolina and 1 other locations · NCT05932199

• Integrating food prescriptions with best feeding practices for families

  This study is testing whether combining food prescriptions with good feeding practices can help families with young children improve their eating habits.

  Recruiting Baylor College of Medicine · Houston, Texas · NCT05881759

• Investigating brain circuits related to mood in humans

  This study is testing how brain activity relates to mood changes in people with depression and whether brain stimulation can help improve their mood.

  Recruiting Baylor College of Medicine · Houston, Texas · NCT05871372

• Neoadjuvant immunochemotherapy for resectable colon cancer

  This study is testing a new combination of immunotherapy and chemotherapy before surgery to see if it helps people with early-stage colon cancer.

  Recruiting Phase 2 Baylor College of Medicine · Houston, Texas · NCT05870800

• Study on how carotenoids in diet affect young children's health

  This study looks at how eating colorful fruits and vegetables affects the health and vision of young children by checking the levels of carotenoids in their blood and skin.

  Recruiting Baylor College of Medicine · Houston, Texas · NCT05869760

• High dose albumin treatment for patients with refractory ascites

  This study is testing if high-dose albumin infusions can help people with advanced liver cirrhosis and fluid buildup in the abdomen feel better and avoid extra procedures.

  Recruiting Phase 2 Baylor College of Medicine · Houston, Texas · NCT05867602

• Improving therapy for veterans with PTSD and anxiety

  This study is testing whether individual or group therapy can help veterans and service members with PTSD and anxiety feel better compared to regular care.

  Recruiting Baylor College of Medicine · Houston, Texas · NCT05843695

• Moderate exercise program for adolescents and young adults with Marfan syndrome

  This study is testing whether a moderate exercise program can help teenagers and young adults with Marfan syndrome feel better both physically and mentally.

  Recruiting Baylor College of Medicine · Houston, Texas · NCT05809323

• Helping families with food insecurity and caregiver mental health

  This study is trying to see if helping mothers with depression and families struggling to get enough food can improve their mental health and strengthen their relationships with their children.

  Recruiting Baylor College of Medicine · Houston, Texas · NCT05809115

• Support program for women recovering from ovarian cancer

  This study is testing a new online support program for women who have finished treatment for ovarian cancer to see if it improves their quality of life compared to standard care.

  Recruiting at 2 sites Baylor College of Medicine · Dallas, Texas and 2 other locations · NCT05752448

• Database for children with severe obesity

  This study is collecting information from young children with severe obesity to better understand how it develops and find out who might need extra help.

  Recruiting Baylor College of Medicine · Houston, Texas · NCT05747976

• Fetal repair of complex gastroschisis using a fetoscopic approach

  This trial will try a minimally invasive fetoscopic surgery, with preoperative Botox, to repair complex gastroschisis before birth in eligible pregnant people between about 20 and 28 weeks to see if it lowers newborn complications and death.

  Recruiting Baylor College of Medicine · Houston, Texas · NCT05704257

• Evaluating devices for repairing neural tube defects in fetoscopic procedures

  This study is testing new tools to see if they make it safer and easier to fix neural tube defects in unborn babies during a special type of surgery.

  Recruiting Baylor College of Medicine · Houston, Texas · NCT05672849

• Comparing His and Left Bundle Branch Pacing for Heart Failure

  This study is testing whether a new way of pacing the heart can help people with heart failure feel better and stay out of the hospital compared to the usual treatment.

  Recruiting at 62 sites Baylor College of Medicine · Gilbert, Arizona and 70 other locations · NCT05650658

• Using CBT to help kids with OCD stop medication safely

  This study is testing if kids and teens with OCD can safely stop their medication after getting extra help from online therapy.

  Recruiting Baylor College of Medicine · Houston, Texas · NCT05609916

• Wireless monitoring of cerebrospinal fluid flow in hydrocephalus patients

  This study is testing a new wireless device that helps monitor fluid flow in the brains of people with hydrocephalus to see if it can improve their care and reduce hospital visits.

  Recruiting Baylor College of Medicine · Houston, Texas · NCT05546996

• Examining brain connectivity in suicidal opioid users

  This study is trying to see if a brain stimulation treatment can help reduce cravings and suicidal thoughts in people who use opioids.

  Recruiting Baylor College of Medicine · Houston, Texas · NCT05489042

• Cortical rTMS for Depression

  This study tests repetitive transcranial magnetic stimulation (rTMS) targeting the orbitofrontal cortex to see if it improves depressive symptoms in adults with major depressive disorder, including those with opioid use and suicidality considerations.

  Recruiting Baylor College of Medicine · Houston, Texas · NCT05487911

• Mapping and Modulating Social and Emotional Processing in the Brain

  This study is testing a new way to understand and improve how people with treatment-resistant epilepsy and depression process social and emotional information by using special brain monitoring techniques.

  Recruiting Baylor College of Medicine · Houston, Texas · NCT05418894

• Understanding TANGO2-related Disorder and Creating a Biorepository

  This study is collecting samples from people with TANGO2 deficiency to learn more about the condition and help find better treatments.

  Recruiting Baylor College of Medicine · Houston, Texas · NCT05374616

• Growth hormone therapy for veterans with Gulf War Illness and hormone deficiency

  This study is testing if growth hormone therapy can help veterans with Gulf War Illness and hormone deficiency feel better by reducing symptoms like fatigue and pain.

  Recruiting at 2 sites Phase 2 Baylor College of Medicine · Houston, Texas and 1 other locations · NCT05355272

• Using light exposure to help pediatric brain tumor survivors with fatigue and cognitive issues

  This study is testing if bright light exposure can help children and teens who survived brain tumors feel less tired and think better.

  Recruiting Baylor College of Medicine · Houston, Texas · NCT05340881

• Improving care for cancer survivors with chronic conditions

  This study is testing a new care approach to see if it can help cancer survivors with other health issues get better support and improve their overall health.

  Recruiting Baylor College of Medicine · Houston, Texas · NCT05323409

• Remote genetic evaluation for children with rare disorders

  This study is testing a new online service to help kids with rare disorders along the Texas-Mexico border get faster genetic evaluations and better healthcare support.

  Recruiting Baylor College of Medicine · Edinburg, Texas · NCT05318222

• IV Iron treatment for anemia in women with uterine bleeding

  This study is testing whether an IV iron treatment works better than oral iron for women with severe anemia caused by heavy bleeding.

  Recruiting Phase 3 Baylor College of Medicine · Houston, Texas · NCT05304442

• Understanding brain responses in epilepsy patients

  This study is testing how the brains of epilepsy patients respond to thinking tasks to better understand their behavior and help improve treatments.

  Recruiting at 2 sites Baylor College of Medicine · Los Angeles, California and 2 other locations · NCT05283811

• Uterine transplant for women with infertility due to absence of uterus

  This study is testing if a uterine transplant from a donor can help women with no uterus due to infertility become pregnant and have a baby.

  Recruiting Baylor College of Medicine · Houston, Texas · NCT05263076

• Combination of FOLFIRINOX and Pembrolizumab followed by surgery for resectable pancreatic cancer

  This study is testing a combination of chemotherapy and an immune therapy to see if it can help people with early-stage pancreatic cancer before they have surgery.

  Recruiting at 3 sites Phase 2 Baylor College of Medicine · Houston, Texas and 2 other locations · NCT05132504

• New CAR-T Cell Therapy for Relapsed B-Cell Leukemia

  This study is testing a new type of CAR-T cell therapy to see if it can help people with relapsed B-cell leukemia by using their own modified immune cells after chemotherapy.

  Recruiting Phase 1 Baylor College of Medicine · Houston, Texas · NCT05010564

• Using HER2 CAR T cells with checkpoint inhibitors for advanced sarcoma

  This study is testing a new treatment that combines personalized CAR T cells with immune boosters to see if it helps people with advanced HER2-positive sarcoma.

  Recruiting Phase 1 Baylor College of Medicine · Houston, Texas · NCT04995003

• Evaluating liver tissue in patients with urea cycle disorders

  This study looks at liver tissue from people with urea cycle disorders to see how these conditions affect the liver, especially in those who have had a liver transplant or biopsy.

  Recruiting Baylor College of Medicine · Washington D.C., District of Columbia and 1 other locations · NCT04908319

• Using engineered T cells to treat pediatric solid tumors

  This study is testing a new treatment using specially modified immune cells to see if they can help children with certain types of solid tumors, like liver cancer and rhabdomyosarcoma, feel better.

  Recruiting Phase 1 Baylor College of Medicine · Houston, Texas · NCT04715191

• Using EBV-specific T cells to treat EBV-positive lymphomas

  This study is testing if specially modified T cells that target the Epstein-Barr virus can help people with certain types of lymphoma that haven't responded to other treatments.

  Recruiting Phase 1 Baylor College of Medicine · Houston, Texas and 3 other locations · NCT04664179

• Evaluating uterine manipulation during minimally invasive surgery for early stage endometrial cancer

  This study is testing if using a tool to help move the uterus during surgery for early stage endometrial cancer affects the spread of cancer cells in the surgical fluid.

  Recruiting at 4 sites Baylor College of Medicine · Cleveland, Ohio and 4 other locations · NCT04586959

• C7R-GD2 CAR T cells for brain tumors expressing GD2

  This study is testing a new treatment using specially modified immune cells to see if they can help people with certain types of brain tumors that have a specific protein called GD2.

  Recruiting Phase 1 Baylor College of Medicine · Houston, Texas · NCT04099797

• Using cobimetinib to treat refractory Langerhans cell histiocytosis and other histiocytic disorders

  This study is testing if a drug called cobimetinib can help people with hard-to-treat Langerhans cell histiocytosis and other similar disorders feel better.

  Recruiting at 10 sites Phase 2 Baylor College of Medicine · Phoenix, Arizona and 11 other locations · NCT04079179

• Using virus-specific T cells to treat infections after stem cell transplants

  This study is testing whether giving special immune cells from a donor can help patients who had a stem cell transplant fight off viral infections.

  Recruiting at 2 sites Phase 1 Baylor College of Medicine · Houston, Texas and 1 other locations · NCT04013802

• Fetal tracheal occlusion to improve lung development in fetuses with severe congenital diaphragmatic hernia

  This study is testing whether a procedure that temporarily blocks the trachea of fetuses with severe congenital diaphragmatic hernia can help their lungs develop better and improve their chances of survival at birth.

  Recruiting Baylor College of Medicine · Houston, Texas · NCT03980717

• Evaluating how race and ethnicity affect treatment response in prostate cancer

  This study is testing how well standard prostate cancer treatments work for men of different races and ethnicities, especially African American men, to see if these factors affect their treatment outcomes.

  Recruiting at 2 sites Phase 2 Baylor College of Medicine · Houston, Texas and 2 other locations · NCT03833921

• Combining a special virus with immune cells to treat advanced HER2 positive cancers

  This study is testing a new treatment that combines a special virus and immune cells to see if it can help people with advanced HER2 positive cancers.

  Recruiting Phase 1 Baylor College of Medicine · Houston, Texas · NCT03740256

• Effect of Dexmedetomidine on Sevoflurane in Young Children

  This study is testing how different doses of a medication called Dexmedetomidine can change the amount of anesthesia needed for young children during surgery.

  Recruiting Phase 4 Baylor College of Medicine · Houston, Texas · NCT03384563

• Using modified T cells to treat relapsed lymphoma

  This study is testing if specially modified T cells can help people with relapsed Hodgkin's and Non-Hodgkin lymphoma fight their cancer more effectively after chemotherapy.

  Recruiting at 2 sites Phase 1 Baylor College of Medicine · Houston, Texas and 1 other locations · NCT02917083

• Comparing vinblastine/prednisone and cytarabine for treating Langerhans Cell Histiocytosis

  This study is testing whether a combination of vinblastine and prednisone works better than cytarabine alone for treating Langerhans Cell Histiocytosis in kids and young adults.

  Recruiting at 10 sites Phase 3 Baylor College of Medicine · Palo Alto, California and 10 other locations · NCT02670707

• Using Twizzlers to screen for gestational diabetes

  This study is testing if eating 10 Twizzlers can be a good way to check for gestational diabetes in pregnant women, instead of the usual sugary drink.

  Recruiting Baylor College of Medicine · Houston, Texas · NCT02610179

• Long-term follow-up of individuals with Osteogenesis Imperfecta

  This study is tracking 1,000 people with Osteogenesis Imperfecta over five years to see how the condition affects their bones, spine, and dental health, which will help improve future treatments.

  Recruiting at 12 sites Baylor College of Medicine · Phoenix, Arizona and 11 other locations · NCT02432625

• Standardized prenatal care for fetuses with urethral obstruction

  This study is trying out a new standard care plan for pregnant women whose babies have been diagnosed with a urinary blockage to see if it helps improve outcomes for both mom and baby.

  Recruiting Baylor College of Medicine · Houston, Texas · NCT02315521

• Repairing complex aortic aneurysms with a specialized stent-graft

  This study is testing a special stent-graft to see if it safely and effectively repairs complex aortic aneurysms in patients who have them.

  Recruiting Baylor College of Medicine · Rochester, Minnesota and 2 other locations · NCT02089607

• Infection of healthy adults with hookworm larvae to test a vaccine

  This study is testing a new hookworm vaccine in healthy adults to see if it can protect them from getting infected after being exposed to hookworm larvae.

  Recruiting Phase 1 Baylor College of Medicine · Washington D.C., District of Columbia · NCT01940757

• Repairing complex abdominal aortic aneurysms with specialized stent grafts

  This study is testing if special stent grafts can safely and effectively repair complex abdominal aortic aneurysms in patients with specific types of these aneurysms.

  Recruiting Baylor College of Medicine · Rochester, Minnesota and 1 other locations · NCT01937949

• Using modified T-cells to treat advanced B-cell cancers

  This study is testing whether modified T-cells can help patients with advanced B-cell cancers that haven't responded to other treatments by boosting their immune system to fight the cancer better.

  Recruiting at 2 sites Phase 1 Baylor College of Medicine · Houston, Texas and 1 other locations · NCT01853631

• Using special T cells to treat EBV-positive lymphoma

  This study is testing a new treatment using special T cells to help people with EBV-positive Hodgkin's or non-Hodgkin lymphoma fight their cancer.

  Recruiting at 2 sites Phase 1 Baylor College of Medicine · Houston, Texas and 2 other locations · NCT01555892

• Using a special method to prepare stem cells from a close relative for transplant

  This study is testing a new way to prepare stem cells from a family member for patients who need a transplant but don’t have a perfect match, to see if it helps them do better after the procedure.

  Recruiting at 2 sites Baylor College of Medicine · Houston, Texas and 1 other locations · NCT01189786

• Investigating the genetic causes of Aicardi syndrome

  This study is trying to find out the genetic causes of Aicardi syndrome by looking at blood and skin samples from patients and their parents.

  Recruiting Baylor College of Medicine · Houston, Texas · NCT00697411

NIH-funded research (newest 40 of 1254)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Multimodal AI to improve genetic diagnosis of congenital heart disease

  A new AI tool uses multiple types of patient data to help doctors find genetic causes of congenital heart disease more accurately.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11625643

• Surveillance of Vaccine-Preventable Diseases in Children

  This project watches how often common vaccines prevent illnesses in kids who are in the hospital or at the emergency department, and compares them with healthy children getting well-child care.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11624114

• Triple gene therapy approach to heal the heart after a heart attack

  A new therapy combines three genetic approaches delivered by a virus to help the heart heal after a heart attack.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11621120

• Thalamic sleep circuit changes in Alzheimer's disease

  Aims to understand how sleep-related brain activity in a key sleep regulator called the TRN affects Alzheimer’s progression and whether boosting TRN function could slow symptoms.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11617739

• Cardiomyocyte-fibroblast signaling in atrial fibrillation

  A researcher at Baylor College of Medicine is studying how signals between heart muscle cells and supportive heart cells influence atrial fibrillation, with the goal of finding new ways to prevent or treat this common heart rhythm problem.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11617730

• UMPIRE: Keeping Kidneys Healthy for Babies with Spina Bifida

  A care protocol for newborns with spina bifida aims to protect kidney function by thoughtful bladder management and monitoring from birth.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11616581

• Translational breast cancer research to improve treatment options

  A comprehensive program at Baylor College of Medicine is focusing on breast cancer; researchers will advance targeted therapies and biomarkers to help patients with aggressive or hard-to-treat forms.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11616352

• How dying brain cells are recognized and cleaned up by the body’s immune cells

  Researchers study how dead brain cells are detected and engulfed by immune cells to prevent further brain damage.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11614125

• Mechanisms of muscle disease in myotonic dystrophy type 1

  This project looks at why skeletal muscles weaken and waste away in adults with myotonic dystrophy type 1 and aims to uncover the underlying molecular causes.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11597907

• Digital biomarkers for Alzheimer’s disease using voice and AI

  Aims to see if voice and language patterns can indicate Alzheimer’s disease before symptoms show up, using existing cohort data and new audio tests.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11597081

• SMAD5 and PCOS/PMOS: a new genetic clue to infertility

  A research project at Baylor College of Medicine is studying a genetic variant in SMAD5 that may cause a form of PCOS/PMOS and could lead to new ways to diagnose or treat infertility.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11595517

• Post-COVID Neuro-Cognitive Changes in Older African Americans

  A study explores how COVID-19 affects thinking, memory, and daily life in older African American adults and what might be driving these changes.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11577296

• Multimodal AI to improve genetic diagnosis of congenital heart disease

  A big AI project will help doctors and families by better identifying genetic causes of congenital heart defects using imaging, medical data, and genome information.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11573169

• Pediatric gastroparesis: building a nationwide patient registry

  This grant funds a national registry to study gastroparesis and similar tummy problems in children and teens, with the goal of better understanding how the condition affects their daily lives.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11567122

• Collaborative Pediatric Critical Care Clinical Site (CPCCRN)

  A nationwide network is testing personalized care approaches for seriously ill children with sepsis to improve outcomes.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11565056

• Molecular mechanisms of cellular response to age-associated chromatin changes

  A study in yeast examines how aging-related changes to chromatin trigger a stress response that, when moderately activated, may extend lifespan and point to ways to counter aging.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11549610

• Knee Joint Nerve Mapping and Pain Pathways

  Aims to map and understand the nerve connections and how pain signals are carried from the knee in adults with osteoarthritis.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11541944

• RADIANT: a network to understand rare and unusual diabetes forms

  A national network collects DNA, RNA, blood, and patient data from people with unusual diabetes to identify new types and understand what causes them.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11538921

• Rare and Atypical Diabetes Network (RADIANT)

  A national network studies unusual forms of diabetes to understand their causes and find better ways to diagnose and treat them.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11538870

• Epigenetic clues to diagnose rare undiagnosed disorders

  Researchers are looking at how epigenetic changes help explain rare diseases in children who still don’t have a clear genetic diagnosis.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11536778

• UDN Diagnostic Center of Excellence at Baylor College of Medicine

  A dedicated center in Baylor College of Medicine helps people with complex, undiagnosed conditions get faster and better diagnostic answers using advanced genetic testing and new methods.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11536659

• Urine-derived cells to help diagnose undiagnosed rare diseases

  This project checks whether RNA sequencing from urine cells can reveal disease-causing gene changes in people with rare, undiagnosed conditions when blood or tissue samples aren’t helpful.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11536611

• AI-guided microendoscopy to detect esophageal cancer早期

  A doctor-research team is testing an AI-assisted microendoscopy tool to screen people at risk for esophageal cancer, aiming to find cancer early with higher accuracy and fewer unnecessary biopsies.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11535395

• AI-assisted Microendoscopy to Detect Esophageal Cancer Earlier

  A technology-based approach uses AI and a tiny endoscopy device to screen for early esophageal cancer, focusing on high-risk regions around the world.</n>

  NIH research Baylor College of Medicine · Houston, United States · NIH-11535393

• Baylor IDDRC focuses on understanding and treating 17p- syndrome

  A Baylor College of Medicine research center is expanding its work to understand the causes of IDD, including 17p- syndrome, and to develop therapies that could help kids and adults with these conditions.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11532977

• Understanding how RNA splicing changes drive cell behavior in disease

  This project explores how alternative RNA splicing influences cell state changes linked to diseases like fibrosis and cancer, with a focus on EMT.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11529934

• Maglev LVAD with a slip-resistant inlet and anti-thrombosis coating to improve blood compatibility

  A new magnetic-levitation heart pump design aims to reduce bleeding and clotting in people with advanced heart failure.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11529217

• Connecting the universe of microbial proteins to uncover functions for disease relevance

  A project using computer analyses of many microbial genomes to link unknown proteins to known ones, creating a web tool to help researchers understand how these proteins relate to virulence and antibiotic resistance.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11526380

• Understanding why youth develop type 2 diabetes and how to prevent it

  A study at Baylor College of Medicine is exploring why some youths with obesity develop type 2 diabetes during puberty and how to stop it from getting worse.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11518277

• Gasdermin-D and IL-1 in Atrial Arrhythmia

  This project explores how a specific inflammatory pathway might drive atrial fibrillation and whether targeting it could reduce rhythm problems.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11508179

• Baylor's Mendelian Genomics Center

  This project uses advanced genome sequencing, data sharing, and lab testing to find genetic causes of rare, undiagnosed conditions for patients and families.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11505433

• FKBP5's role in heart rhythm and potential AF therapies

  A Baylor College of Medicine team is studying how FKBP5 in the heart affects atrial fibrillation and whether targeting this pathway could lower AF risk.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11503065

• FKBP5’s role in heart rhythm and new AF therapies

  This grant studies how FKBP5 affects atrial fibrillation and whether targeting FKBP5 could reduce AF risk.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11503047

• Viruses and immune responses linked to islet autoimmunity and type 1 diabetes in children

  This project looks at viruses and immune cells in blood, nasal swabs, plasma, and stool from young children to understand how prolonged enterovirus infections may lead to early autoimmune changes that cause type 1 diabetes.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11501041

• Viral infections and immune responses in early islet autoimmunity and type 1 diabetes

  Researchers will look at blood, nasal swabs, stool, and plasma from children to see whether long-lasting enterovirus infections and immune changes are linked to early islet autoimmunity and type 1 diabetes.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11501040

• Genetics-based matching to prevent or slow type 1 diabetes

  This project uses genetic information to find adults with or at risk for type 1 diabetes who are most likely to benefit from treatments that prevent or slow the disease.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11479587

• Metasurface Optical Guidewire to Treat Coronary Artery Calcification

  A new optical guidewire technology aims to improve safety and effectiveness of coronary interventions in people with calcified arteries.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11468164

• Coordinated platform to grow transplant-ready bioartificial heart tissue

  A research program at Baylor aims to develop an automated, bioreactor system that grows and trains human heart tissue using stem cells to create a transplantable heart chamber.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11465488

• How Periosteal Stem Cells Help Bone Heal Better as We Age

  Aging bones heal more slowly, and this project looks at how outer bone stem cells (perisosteal stem cells) could be activated to make bones stronger and fix injuries more reliably in adults.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11465082

• Negative Regulation of SOX4 in liver bile duct development (Alagille syndrome)

  A patient-focused study aims to understand how a gene called SOX4 affects bile duct growth in a genetic liver condition called Alagille syndrome, with the goal of finding new ways to help affected children.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11465056

Quick answers

How many clinical trials run by Baylor College of Medicine are recruiting right now?

100, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 4 countries. The most sites are in United States (99 trials), Canada (2 trials), Malawi (1 trial), Brazil (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 21, Phase 2: 10, Phase 3: 2, Phase 4: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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