Database for children with severe obesity
Official title: Genetic Disorders of Obesity Program Database
Run by Baylor College of Medicine · NCT05747976 · Data updated 2026-11-12
This study is collecting information from young children with severe obesity to better understand how it develops and find out who might need extra help.
Quick facts
| Study type | Observational |
|---|---|
| Sex | All |
| Enrollment | 500 (estimated) |
| Sponsor | Baylor College of Medicine Academic / other |
| Locations | 1 site (Houston, Texas) |
| Status | Recruiting |
| Started | August 30, 2020 |
| Main results expected | December 31, 2030 |
| Study ends | December 31, 2030 |
| Registry record updated | May 12, 2026 |
| Trial ID | NCT05747976 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are children aged 2 years and older with a BMI greater than the 97th percentile or those under 2 years with a weight-to-length ratio above the 95th percentile.
✕Probably not a fit
Patients who do not meet the specified BMI or weight-to-length criteria may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study collects data on children and adolescents who have experienced severe weight gain before the age of five. Participants are recruited from the Genetic Disorders of Obesity Program at Texas Children, where demographic information, body measurements, medical and family history, and genetic data are gathered. The aim is to enhance understanding of obesity development in these young patients and identify those who may benefit from further testing and interventions.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of severe obesity in children, potentially guiding personalized treatment strategies.
How similar studies have gone: While there have been studies on obesity, this specific approach focusing on genetic disorders of obesity in young children is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * For individuals 2 years and older, BMI \> 97 percentile * For individuals \< 2 years old, weight-to-length ratio \> 95th percentile Exclusion Criteria: * No other exclusion criteria
Where it's running
-
Baylor College of Medicine
Houston, Texas, United States Recruiting
Study contacts
- Study coordinator: Stephanie Sisley, MD
- Email: Sisley.lab@bcm.edu
- Phone: 713-798-0391
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Wise Interventions to Boost Pediatric Weight Control
This study tests whether adding two quick social-psychology activities (growth mindset and self-affirmation) to a family-based weight management program helps 10–15 year-olds with obesity achieve better BMI outcomes over 12 months.
-
Newborn whole-genome sequencing and genetic disease risk in pregnancy and early life
This project will collect small biological samples from pregnant families and newborns to try whole-genome sequencing and other multi-omics tests to find genetic disease risks.
-
Multicenter study of SHANK3-related Phelan-McDermid syndrome genetic modifiers
Researchers are testing how other genes may modify the PMS clinical picture in people with SHANK3-related deletions or variants.
-
Prenatal cfDNA Screening in Pregnancies with Diverse Genetic Risk Profiles
This study tests two cfDNA approaches from a single maternal blood sample to see if they can detect a wide range of fetal genetic conditions in pregnant people with various risk factors.
-
Natural history of type I interferonopathies in a European patient group
This project will follow people with genetically confirmed type I interferonopathies across European centers to see how the disease develops and which clinical and blood markers track disease activity.
-
Speech-generating device to help communication in childhood dementia
This project will test whether giving children with childhood dementia a speech-generating iPad app helps them communicate better than their usual care.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.