Viral infections and immune responses in early islet autoimmunity and type 1 diabetes
Official title: Virome and Immune Responses associated with IA and Type 1 Diabetes
Funded at Baylor College of Medicine · NIH-11501040 · Data updated 2026-11-12
Researchers will look at blood, nasal swabs, stool, and plasma from children to see whether long-lasting enterovirus infections and immune changes are linked to early islet autoimmunity and type 1 diabetes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | March 5, 2024 |
| Project end | January 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $145,543 |
| NIH project number | 3R01DK138372-03S1 |
| Project ID | NIH-11501040 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children from the TEDDY cohort with stored stool, blood, nasal swabs, or plasma samples—especially those who developed islet autoimmunity or type 1 diabetes by age six—are the focus of this analysis.
✕Less likely to help
Adults, children without available stored samples, or people with non-autoimmune causes of diabetes would not directly benefit from this specific sample-based project.
What this research studies
This project uses stored blood, nasal swabs, stool, and plasma from 450 children already enrolled in the TEDDY study. Researchers will search those samples for prolonged enterovirus infections using PCR and sequencing and combine that with detailed single-cell multi-omic analysis of immune cells. They will compare children who developed islet autoimmunity or type 1 diabetes by age six with children who did not to identify viral and immune patterns tied to disease. The work aims to reveal how long-lasting infections may trigger autoimmune changes before diabetes appears.
Why it matters
Potential benefit: If successful, this work could identify viral or immune markers that help detect or prevent type 1 diabetes earlier in children.
How similar studies have gone: Previous TEDDY analyses and other studies have linked enterovirus infections to islet autoimmunity, but applying longitudinal virome data with single-cell multi-omic immune profiling is a newer, more detailed approach.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Lloyd, Richard E — Baylor College of Medicine
- Study coordinator: Lloyd, Richard E
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.