Effect of Dexmedetomidine on Sevoflurane in Young Children

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to evaluate how two different dosages of Dexmedetomidine (0.5mcg/kg and 1mcg/kg) influence the minimum alveolar concentration (MAC) of Sevoflurane in children aged 1 month to 3 years. The MAC is a critical measure of anesthetic potency, indicating the dose required to prevent movement in response to surgical stimuli. By assessing the effects of Dexmedetomidine on MAC, the study seeks to optimize anesthesia protocols for pediatric patients undergoing surgery. The research will involve children from three age groups: 1-6 months, 6-12 months, and 12-36 months.

Why it matters

Who can join: the full rules

Exclusion Criteria:

1. Interstitial lung disease, chest wall disease, or bronchospastic disease with no flare-ups in the past 2 weeks of presentation
2. History of difficult intubation or ventilation
3. Airway malformation
4. Congenital heart disease
5. Cardiac arrhythmias
6. Central nervous system disease, including developmental delay, cerebral palsy, or seizure disorder
7. History of or family history of malignant hyperthermia
8. Electrolyte disorders
9. Gastrointestinal disease
10. Hepatic dysfunction
11. Renal dysfunction
12. Metabolic disease, such as diabetes
13. Obesity, defined as a body mass index greater than the 95% percentile for age
14. Preterm infant (less than 37 weeks gestational age) 15. Use of any medications (anticonvulsants, opioids, benzodiazepines, antibiotics, antihistamines drugs that induce hepatic enzymes) that may affect MAC.

Inclusion Criteria

All patients age 1 month- 3 years presenting for surgery.

Where it's running

• Texas Children's Hospital
  Houston, Texas, United States Recruiting

Study contacts

• Principal investigator: Rahul Baijal, MD — Baylor College of Medicine
• Study coordinator: Margaret Owens-Stuberfield
• Email: owensstu@bcm.edu
• Phone: 832-824-5800

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.