Baylor's Mendelian Genomics Center
Official title: Baylor College of Medicine - Mendelian Genomics Research Center (BCM-MGRC)
Funded at Baylor College of Medicine · NIH-11505433 · Data updated 2026-11-12
This project uses advanced genome sequencing, data sharing, and lab testing to find genetic causes of rare, undiagnosed conditions for patients and families.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | February 25, 2026 |
| Project end | April 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $2,061,941 |
| NIH project number | 3U01HG011758-05S1 |
| Project ID | NIH-11505433 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are people or families with a suspected genetic rare disease that remains unsolved after standard clinical testing such as exome sequencing.
✕Less likely to help
People whose conditions are not genetic or whose diagnosis has already been established by prior testing are unlikely to benefit from this program.
What this research studies
If you join, you'll become part of a large program that has enrolled about 18,000 people and families with rare conditions that routine clinical tests did not solve. The team combines deep genomic sequencing, new analytic tools, data sharing across research networks, and laboratory tests in cells or animals to check whether candidate genes or variants cause disease. They will also finish processing remaining participant samples and consolidate all collected data to support final analyses. Results and data are shared within the GREGoR network and public platforms to help match cases and speed new discoveries.
Why it matters
Potential benefit: Successful work could provide genetic diagnoses for people with previously unexplained conditions, guiding medical care, genetic counseling, and future research on treatments.
How similar studies have gone: Previous Mendelian genomics programs, including prior Baylor efforts, have successfully identified many new disease genes using similar approaches, though some cases remain unsolved.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Gibbs, Richard a — Baylor College of Medicine
- Study coordinator: Gibbs, Richard a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.