Understanding TANGO2-related Disorder and Creating a Biorepository
Official title: Natural History Study and Establishment of a Biorepository-TANGO2-related Disorder
Run by Baylor College of Medicine · NCT05374616 · Data updated 2026-11-12
This study is collecting samples from people with TANGO2 deficiency to learn more about the condition and help find better treatments.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 0 Days and up |
| Sex | All |
| Enrollment | 300 (estimated) |
| Sponsor | Baylor College of Medicine Academic / other |
| Locations | 1 site (Houston, Texas) |
| Status | Recruiting |
| Started | May 18, 2018 |
| Main results expected | January 1, 2030 |
| Study ends | January 1, 2030 |
| Registry record updated | October 1, 2025 |
| Trial ID | NCT05374616 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are individuals diagnosed with pathogenic TANGO2 variants.
✕Probably not a fit
Patients without TANGO2-related disease will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study focuses on individuals with TANGO2 deficiency, a rare genetic disorder that can lead to severe health issues such as rhabdomyolysis and cardiac arrhythmias. The study aims to establish a biorepository of biological samples from affected individuals to support scientific research and create a comprehensive clinical database. By understanding the natural history of the disease, researchers hope to gain insights into its mechanisms and develop potential therapies to improve patient outcomes.
Why it matters
Potential benefit: If successful, this study could lead to better understanding and management of TANGO2-related disorder, ultimately improving patient care.
How similar studies have gone: While this study is focused on a rare condition, similar approaches in establishing biobanks for genetic disorders have shown promise in advancing understanding and treatment options.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: All patients with pathogenic TANGO2 variants will be included. Exclusion Criteria: Patients who do not have TANGO2-related disease will be excluded.
Where it's running
-
Baylor College of Medicine
Houston, Texas, United States Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.