Understanding brain responses in epilepsy patients
Mapping Algorithmic State Space in the Human Brain
This study is testing how the brains of epilepsy patients respond to thinking tasks to better understand their behavior and help improve treatments.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 205 (estimated) |
| Ages | 10 Years to 64 Years |
| Sex | All |
| Sponsor | Baylor College of Medicine Academic / other |
| Locations | 3 sites (Los Angeles, California and 2 other locations) |
| Trial ID | NCT05283811 on ClinicalTrials.gov |
What this trial studies
This study investigates how the brain's prefrontal and medial temporal regions respond to cognitive tasks in epilepsy patients. By utilizing the NeuroPace RNS system and monitoring local-field potentials, researchers aim to uncover the neurophysiological mechanisms behind adaptive behavior in novel situations. The focus is on patients who have intracranial electrodes placed for clinical evaluation of their epilepsy, allowing for detailed observation of neuronal activity during cognitive tasks. The findings could enhance our understanding of cognitive flexibility in epilepsy and inform future therapeutic strategies.
Who should consider this trial
Good fit: Ideal candidates for this study are male and female epilepsy patients aged 10 to 64 who are undergoing placement of intracranial electrodes.
Not a fit: Patients who are unable to understand instructions or concentrate sufficiently to respond correctly may not benefit from this study.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment approaches for epilepsy by enhancing our understanding of cognitive flexibility in affected patients.
How similar studies have performed: While the specific approach of this study is novel, previous research has shown promise in understanding brain responses in epilepsy patients using similar methodologies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Eligible subjects include both male and female patients, between 10 years of age and 64 years of age, who undergo placement of intracranial electrodes for clinical characterization of epilepsy. Exclusion Criteria: * Grounds for exclusion would include inability to understand and follow instructions, or inability to concentrate sufficiently to achieve a high proportion of correct responses.
Where this trial is running
Los Angeles, California and 2 other locations
- University of California, Los Angeles — Los Angeles, California, United States (Recruiting)
- Baylor College of Medicine — Houston, Texas, United States (Recruiting)
- University of Utah — Salt Lake City, Utah, United States (Active_not_recruiting)
Study contacts
- Study coordinator: Sameer Sheth, MD, PhD
- Email: sasheth@bcm.edu
- Phone: 713-798-5060
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.