FKBP5’s role in heart rhythm and new AF therapies
Official title: FKBP5 AND CARDIAC ARRHYTHMOGENESIS
Funded at Baylor College of Medicine · NIH-11503047 · Data updated 2026-11-12
This grant studies how FKBP5 affects atrial fibrillation and whether targeting FKBP5 could reduce AF risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | December 20, 2023 |
| Project end | November 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $58,398 |
| NIH project number | 3R01HL164838-03S1 |
| Project ID | NIH-11503047 on NIH RePORTER |
Who could benefit from this research
✓Could help
People with atrial fibrillation or those at risk who could benefit from new AF therapies.
✕Less likely to help
If AF is not present or the FKBP5 pathway is not relevant to a patient’s condition, direct benefits may be limited.
What this research studies
Atrial fibrillation is the most common heart rhythm problem. The project investigates how low FKBP5 in heart tissue may drive abnormal heart rhythms and fibrosis. Researchers will look at how FKBP5 loss in heart muscle cells and in supporting heart cells contributes to AF, with the goal of uncovering new therapeutic ideas. The work combines laboratory experiments to understand mechanisms with tests that could point toward treatments to lower AF risk.
Why it matters
Potential benefit: If successful, the findings could lead to new approaches to prevent or treat atrial fibrillation by modulating FKBP5 pathways.
How similar studies have gone: Preliminary data suggest FKBP5 influences heart rhythm, but detailed cardiac mechanisms remain to be clarified and are being explored here.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Li, Na — Baylor College of Medicine
- Study coordinator: Li, Na
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.