Postoperative Pain After Pediatric Adenotonsillectomy: Ibuprofen Plus Tylenol vs Ketorolac Plus Tylenol

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective observational study compares two non-opioid discharge regimens after outpatient pediatric adenotonsillectomy: acetaminophen with ibuprofen versus acetaminophen with low-dose oral ketorolac. Participants will report pain severity, medication use, and functional recovery via text messages for up to 14 days post-discharge. Outcomes include postoperative pain experiences, incidence of severe pain, healthcare utilization, and overall recovery as guided by routine care and surgeon preference. The study is conducted at Baylor College of Medicine and Texas Children’s Hospital in Houston, enrolling adolescents aged 13-18 without major comorbidities.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Scheduled for outpatient adenotonsillectomy Age 13-18 years ASA physical status I-III Patient or parent has access to a phone with text-messaging capability Patient assent Parent or legal guardian consent

Exclusion Criteria:

Inpatient admission or planned 23-hour observation Known hematologic condition or prior bleeding disorder Current anticoagulant use Known or suspected chronic kidney disease or solitary kidney Known or suspected liver disease or prior liver transplant Known or suspected mitochondrial disease or genetic anomaly Inability to self-report pain History of gastrointestinal ulcer or bleeding Allergy to acetaminophen, ibuprofen, or ketorolac Non-English or non-Spanish speaking Chronic pain or condition requiring frequent routine NSAID use Patient refusal Parent or guardian refusal

Where it's running

• Baylor College of Medicine/ Texas Childrens Hospital
  Houston, Texas, United States Recruiting

Study contacts

• Study coordinator: Adam C Adler, MD
• Email: adam.adler@bcm.edu
• Phone: 8328245800

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Ultrasound-guided glossopharyngeal and maxillary nerve blocks for pain control after adenotonsillectomy

  Doctors will test whether adding ultrasound-guided glossopharyngeal and maxillary nerve blocks to usual pain control reduces pain after adenotonsillectomy in children aged 5–13.

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• Oral melatonin versus nebulized dexmedetomidine to reduce emergence agitation after adenotonsillectomy in children

  We will test whether giving oral melatonin or nebulized dexmedetomidine before anesthesia better prevents children aged 3–7 from becoming agitated as they wake after adenotonsillectomy.

  Recruiting Tanta University · Tanta, El-Gharbia · NCT07345715

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.