Triple gene therapy approach to heal the heart after a heart attack
Official title: Triple Gene Therapy for Ischemic Heart Failure
Funded at Baylor College of Medicine · NIH-11621120 · Data updated 2026-11-12
A new therapy combines three genetic approaches delivered by a virus to help the heart heal after a heart attack.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | August 25, 2025 |
| Project end | May 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $559,597 |
| NIH project number | 4R33HL177472-02 |
| Project ID | NIH-11621120 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with a history of myocardial infarction or ischemic heart damage who could benefit from regenerative therapies.
✕Less likely to help
Patients without ischemic heart damage or those unable to undergo gene therapy approaches may not benefit.
What this research studies
This project aims to restore heart muscle after a heart attack by using three complementary strategies: encouraging heart cells to multiply, directly reprogramming scar-forming cells into heart cells, and improving blood vessel formation. The researchers will test these three methods together in preclinical studies to see if they work better when combined. They will also work on a noninvasive way to deliver the therapy so it could be used in people. The goal is to regenerate heart tissue, reduce scarring, and improve heart function.
Why it matters
Potential benefit: If successful, this approach could lead to new treatments that restore heart muscle and function after a heart attack.
How similar studies have gone: Previous single-modality approaches have shown promise in animals or early trials, but the triple therapy is a novel combination.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Mohamed, Tamer M a — Baylor College of Medicine
- Study coordinator: Mohamed, Tamer M a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.