Investigating brain circuits related to mood in humans

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to deepen the understanding of the neural mechanisms underlying depression by utilizing precise intracranial neural recordings in humans. It combines advanced modeling techniques with self-reported mood data and behavioral assessments to decode mood states and their neural correlates. The research includes a transdiagnostic approach to examine how depression affects behavior across various neurobiological dimensions. Additionally, the study explores the effects of brain stimulation on these neural dynamics to derive causal insights into mood modulation.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Epilepsy cohort: adult patients scheduled to undergo intracranial seizure monitoring who provide informed consent
* Depression cohort: patients enrolled in our DBS for depression trial

Where it's running

• Baylor College of Medicine
  Houston, Texas, United States Recruiting

Study contacts

• Study coordinator: Sameer Sheth, MD, PhD
• Email: sameer.sheth@bcm.edu
• Phone: 713-798-5060

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.