Investigating brain circuits related to mood in humans
Intracranial Investigation of Neural Circuity Underlying Human Mood
This study is testing how brain activity relates to mood changes in people with depression and whether brain stimulation can help improve their mood.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 58 (estimated) |
| Ages | 21 Years to 70 Years |
| Sex | All |
| Sponsor | Baylor College of Medicine Academic / other |
| Locations | 1 site (Houston, Texas) |
| Trial ID | NCT05871372 on ClinicalTrials.gov |
What this trial studies
This study aims to deepen the understanding of the neural mechanisms underlying depression by utilizing precise intracranial neural recordings in humans. It combines advanced modeling techniques with self-reported mood data and behavioral assessments to decode mood states and their neural correlates. The research includes a transdiagnostic approach to examine how depression affects behavior across various neurobiological dimensions. Additionally, the study explores the effects of brain stimulation on these neural dynamics to derive causal insights into mood modulation.
Who should consider this trial
Good fit: Ideal candidates include adult patients with epilepsy undergoing intracranial seizure monitoring and patients enrolled in deep brain stimulation trials for depression.
Not a fit: Patients with mild mood disorders or those not undergoing intracranial procedures may not benefit from this study.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for depression and related conditions by providing a clearer understanding of the brain's mood regulation mechanisms.
How similar studies have performed: While there have been studies exploring neural correlates of mood, this approach combining intracranial recordings with explainable AI is relatively novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Epilepsy cohort: adult patients scheduled to undergo intracranial seizure monitoring who provide informed consent * Depression cohort: patients enrolled in our DBS for depression trial
Where this trial is running
Houston, Texas
- Baylor College of Medicine — Houston, Texas, United States (Recruiting)
Study contacts
- Study coordinator: Sameer Sheth, MD, PhD
- Email: sameer.sheth@bcm.edu
- Phone: 713-798-5060
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.