Gasdermin-D and IL-1 in Atrial Arrhythmia
Official title: The Role of Gasdermin-D/Interleukin-1 Nexus in Atrial Arrhythmogenesis
Funded at Baylor College of Medicine · NIH-11508179 · Data updated 2026-11-12
This project explores how a specific inflammatory pathway might drive atrial fibrillation and whether targeting it could reduce rhythm problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | December 1, 2021 |
| Project end | November 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $119,069 |
| NIH project number | 3R01HL136389-09S1 |
| Project ID | NIH-11508179 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are adults with atrial fibrillation or at high risk for AF who could contribute tissue samples or participate in future translational studies.
✕Less likely to help
Patients without AF or related heart conditions may not directly benefit from this research.
What this research studies
Researchers at Baylor College of Medicine will study how the IL-1b and GSDMDNT proteins interact in heart cells to promote atrial fibrillation. They will use mouse models and human atrial tissue to map the role of IL-1 signaling and the GSDMDNT pore-forming activity in creating an arrhythmia-friendly environment. The work aims to confirm whether a GSDMDNT/IL-1b feedforward loop drives NLRP3 inflammasome–related atrial disease and to validate potential intervention points. This could lay the groundwork for future therapies that interrupt this inflammatory cascade to prevent AF.
Why it matters
Potential benefit: If successful, findings could lead to new inflammatory-targeted treatments to reduce AF risk and complications.
How similar studies have gone: Prior studies show that inflammasome pathways influence AF, supporting the potential relevance of this approach.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Li, Na — Baylor College of Medicine
- Study coordinator: Li, Na
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.