UDN Diagnostic Center of Excellence at Baylor College of Medicine
Funded at Baylor College of Medicine · NIH-11536659 · Data updated 2026-11-12
A dedicated center in Baylor College of Medicine helps people with complex, undiagnosed conditions get faster and better diagnostic answers using advanced genetic testing and new methods.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | July 1, 2014 |
| Project end | July 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $160,000 |
| NIH project number | 3U01NS134348-12S1 |
| Project ID | NIH-11536659 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults and children with undiagnosed diseases seeking diagnostic answers and access to expert genomic analyses.
✕Less likely to help
If a patient’s condition is already clearly diagnosed or not related to undiagnosed diseases pathways, direct benefit may be limited.
What this research studies
This grant supports the Baylor College of Medicine Diagnostic Center of Excellence as part of the Undiagnosed Diseases Network, focusing on rapid, precise diagnoses for adults and children with unclear medical problems. The team uses cutting-edge approaches, including RNA sequencing and genome sequencing, to connect genetic variants with diseases. They collaborate with national programs and community health partners to improve access and share innovative practices. The center tracks outcomes and aims to increase the number of solved cases while refining diagnostic workflows for future patients.
Why it matters
Potential benefit: Patients with undiagnosed conditions could receive faster, more accurate diagnoses and better guidance for management and potential treatments.
How similar studies have gone: The program has achieved a measurable solve rate and pioneered RNAseq-first analytics now used more broadly.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Lee, Brendan — Baylor College of Medicine
- Study coordinator: Lee, Brendan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.