Understanding genetic factors in children with eye defects

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to gather data on children diagnosed with Microphthalmia, Anophthalmia, and Coloboma (MAC) to better understand the physical characteristics and genetic mutations associated with these conditions. The research will utilize resources from the Texas Birth Defects Registry and collaborate with institutions like the National Institutes of Health to identify MAC cases and analyze genetic variants. The long-term goal is to enhance prevention and clinical management strategies for MAC by defining its phenotype and characterizing genetic susceptibility.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. All MAC cases
2. Parents of the above children.
3. Siblings of the above children.
4. English or Spanish speaking.

Exclusion Criteria:

All subjects who do not meet the inclusion criteria listed above.

Where it's running

• Baylor College of Medicine
  Houston, Texas, United States Recruiting

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Understanding the genetics of eye development disorders

  This study is trying to find out how genetics play a role in eye development disorders like microphthalmia, anophthalmia, and uveal coloboma by looking at people with these conditions and their family members.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT01778543

• National cohort for congenital eye defects

  This study looks at how congenital eye defects affect vision and development in newborns, children, and adults over ten years to help improve care for those with these conditions.

  Recruiting Institut National de la Santé Et de la Recherche Médicale, France · Paris, Île-de-France Region · NCT05954403

• GelPOINT Path-assisted endoscopic removal of colorectal polyps

  This study tests whether using the GelPOINT Path access platform during endoscopic submucosal dissection can safely help remove colorectal polyps in adults.

  Recruiting Baylor College of Medicine · Houston, Texas · NCT07723937

• Acceptance Based Coping Skills for Hispanic/Latino Military Patients With Type 2 Diabetes

  A bilingual health coach will lead a 10-week telehealth program to help Hispanic/Latino military patients with type 2 diabetes manage their condition better.

  Recruiting Baylor College of Medicine · San Antonio, Texas · NCT07674628

• Postoperative Pain After Pediatric Adenotonsillectomy: Ibuprofen Plus Tylenol vs Ketorolac Plus Tylenol

  This observational study will see if teens (13-18) who have adenotonsillectomy and take acetaminophen with ibuprofen or acetaminophen with ketorolac after discharge experience different levels of pain and recovery.

  Recruiting Baylor College of Medicine · Houston, Texas · NCT07672418

• Non-invasive brain stimulation to try to improve memory in early Alzheimer's

  Scientists test whether repetitive transcranial magnetic stimulation to the cerebellum can help short-term memory in people with early Alzheimer's disease compared with a sham procedure.

  Recruiting Baylor College of Medicine · Houston, Texas · NCT07667478

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.