FKBP5's role in heart rhythm and potential AF therapies
Official title: FKBP5 AND CARDIAC ARRHYTHMOGENESIS
Funded at Baylor College of Medicine · NIH-11503065 · Data updated 2026-11-12
A Baylor College of Medicine team is studying how FKBP5 in the heart affects atrial fibrillation and whether targeting this pathway could lower AF risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | December 20, 2023 |
| Project end | November 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $90,523 |
| NIH project number | 3R01HL164838-03S2 |
| Project ID | NIH-11503065 on NIH RePORTER |
Who could benefit from this research
✓Could help
People with or at risk for atrial fibrillation who might benefit from future FKBP5-targeted therapies.
✕Less likely to help
Patients without AF or AF risk factors may not experience direct benefits from this research.
What this research studies
This research looks at how reducing FKBP5 in heart cells and heart-supporting tissue may lead to atrial fibrillation by increasing abnormal electrical activity and promoting fibrotic changes. The team will use models to separate the effects in heart muscle cells versus fibroblasts, aiming to understand the exact mechanisms. If successful, the work could point to new therapeutic strategies to prevent or treat AF by modulating FKBP5 pathways.
Why it matters
Potential benefit: Could lead to new ways to prevent or treat atrial fibrillation by targeting FKBP5-related mechanisms.
How similar studies have gone: Previous findings that FKBP5 deficiency links to increased AF risk justify exploring this pathway further, with potential for new therapies.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Li, Na — Baylor College of Medicine
- Study coordinator: Li, Na
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.