Moderate exercise program for adolescents and young adults with Marfan syndrome
Official title: Clinical Trial On The Effects Of Moderate Physical Activity On Health And Well-Being In Adolescents And Young Adults With Marfan Syndrome
Run by Baylor College of Medicine · NCT05809323 · Data updated 2026-11-12
This study is testing whether a moderate exercise program can help teenagers and young adults with Marfan syndrome feel better both physically and mentally.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 10 Years to 25 Years |
| Sex | All |
| Enrollment | 50 (estimated) |
| Sponsor | Baylor College of Medicine Academic / other |
| Locations | 1 site (Houston, Texas) |
| Status | Recruiting |
| Started | September 1, 2023 |
| Main results expected | July 1, 2025 |
| Study ends | July 1, 2027 |
| Registry record updated | January 24, 2024 |
| Trial ID | NCT05809323 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are males and females aged 10-25 years diagnosed with Marfan syndrome.
✕Probably not a fit
Patients with a history of aortic surgery or significant aortic dilation may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This trial investigates the effects of moderate dynamic exercise on adolescents and young adults diagnosed with Marfan syndrome, a connective tissue disorder that poses risks to cardiovascular health. Participants will be divided into an exercise intervention group and a control group to assess the impact of exercise on their physical and mental well-being. The study aims to address the lack of data on exercise effects in this population, as many are currently advised against physical activity due to concerns about aortic dissection. By evaluating the outcomes of moderate exercise, the trial seeks to provide evidence that could inform future guidelines for physical activity in patients with Marfan syndrome.
Why it matters
Potential benefit: If successful, this study could lead to improved physical health and quality of life for patients with Marfan syndrome through safe exercise recommendations.
How similar studies have gone: While there are no controlled studies on dynamic exercise in humans with Marfan syndrome, related research in rodent models has shown promising results.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Male and female patients diagnosed with Marfan syndrome (defined by Ghent criteria and either a pathogenic variant in FBN1 or ectopia lentis) * Age 10-25 years at enrollment Exclusion Criteria: 1. History of aortic surgery 2. History of spinal surgery with implanted materials that may negatively impact MRI safety or imaging quality. 3. Diagnosis of major congenital heart disease (ASD, VSD, bicuspid aortic valve, and mitral valve prolapse will not qualify as exclusion criteria) 4. Condition limiting the ability to perform moderate exercise. 5. Major concurrent diagnosis that may confound the interpretation of the effect of the proposed intervention on the proposed outcome measures. 6. Aortic dilation meeting threshold for prophylactic aortic surgical intervention (\>/= 4.5 cm in diameter)
Where it's running
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Texas Children's Hospital
Houston, Texas, United States Recruiting
Study contacts
- Principal investigator: Shaine A Morris, MD, MPH — Baylor College of Medicine
- Study coordinator: Shaine A Morris, MD, MPH
- Email: shainem@bcm.edu
- Phone: 832-826-5692
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Pregnancy-Related Aortic Dissection in China
This study looks at cases of aortic dissection that occur during pregnancy or shortly after, to understand outcomes for mothers and babies.
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Adapted physical activity program to improve endurance in children and teens with Marfan syndrome
This project will try a 6‑month tailored exercise program to see if it improves endurance (VO2 peak) and quality of life in children and teenagers with Marfan syndrome.
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This study looks at why adults with Marfan syndrome seek psychological support and how their condition affects their mental health and coping skills.
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Assessing facial features in Marfan syndrome
This study is trying to identify and track the facial features of people with Marfan syndrome to help with earlier diagnosis and understanding of the condition.
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Collection of biological samples from patients with Marfan syndrome
This study is collecting blood and urine samples from people with Marfan syndrome to help researchers learn more about the condition and how to improve treatment for patients.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.