Tuberculosis treatment pathways and outcomes in France: a national cohort

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The French Tuberculosis Cohort is a prospective, multicenter observational study enrolling adults with active TB who begin inpatient treatment. It collects sociodemographic, clinical, radiologic, and bacteriologic data at scheduled visits, and stores biological samples (blood, urine, breath, hair) and positive mycobacterial strains for biobanking. The study aims to describe patient characteristics, treatment responses, relapse rates, and the influence of comorbidities, social determinants, and new short-course regimens on outcomes up to 24 months. It also explores the impact of immunosuppression, resistant TB, and disease severity on management, adverse events, and survival, with attention to quality of life and access to care.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Aged ≥18 years.
* Diagnosis of tuberculosis by microbiological or clinical means, including on the basis of a pathological examination for extrapulmonary tuberculosis leading to a Compulsory Declaration (CD) and treated for less than 8 days.
* Have signed a voluntary, informed and written consent (at the latest on the day of inclusion and before any examination carried out as part of the research), or alternatively, consent from relatives in cases of tuberculous meningitis or other serious forms of tuberculosis with impaired consciousness or confusion, until the person is able to give their consent.

Exclusion Criteria:

* Presence of significant cognitive impairment that, in the opinion of the site investigator or designated person, may affect the ability to give reliable informed consent (except in the specific case of meningeal tuberculosis).

Where it's running

• Service de pneumologie et maladies infectieuses, Centre hospitalier Delafontaine
  Saint-Denis, France Recruiting
• AP-HP Hôpital Saint Louis - Service des Maladies Infectieuses et Tropicales
  Paris, France Not yet recruiting

Study contacts

• Principal investigator: Nathalie DE CASTRO, MD PHD — Hôpital Saint Louis Paris
• Study coordinator: Olivier MARCY, MD PHD
• Email: olivier.marcy@u-bordeaux.fr
• Phone: +33 5 57 57 17 67

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.