Options for Delivering Short-Course TB Preventive Therapy for People with HIV
Official title: Options for Delivery of Short-Course Tuberculosis Preventive Therapy: The 3HP Options Trial
Funded at University of California-Irvine · NIH-11549390 · Data updated 2026-11-12
A trial tests easier, shorter TB-prevention therapy (3HP) for people living with HIV to see if simplified support helps them complete treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project start | August 1, 2018 |
| Project end | July 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $187,278 |
| NIH project number | 3R01HL144406-08S1 |
| Project ID | NIH-11549390 on NIH RePORTER |
Who could benefit from this research
✓Could help
People living with HIV who are eligible for TB preventive therapy with the 3HP regimen.
✕Less likely to help
Patients not eligible for 3HP or not receiving TB preventive therapy may not benefit from this approach.
What this research studies
If you are living with HIV, this study looks at whether a simplified help plan—like better counseling, telephone reminders, and easy-dose tracking—can help people finish a 12-week TB preventive therapy. It builds on a prior finding that facilitated self-administered therapy improved completion and reduced costs, and it tests whether these components work across multiple clinics. Participants will receive the 3HP regimen with enhanced support compared to routine support to see which method leads to better adherence and outcomes. The aim is to guide scalable, real-world implementation of effective 3HP delivery in HIV clinics.
Why it matters
Potential benefit: If successful, this approach could make TB prevention more effective and affordable for people with HIV.
How similar studies have gone: Prior single-center results showed high completion with facilitated self-administered therapy and lower costs.
Where this research is happening
-
University of California-Irvine
Irvine, United States Active
Researchers
- Principal investigator: Cattamanchi, Adithya — University of California-Irvine
- Study coordinator: Cattamanchi, Adithya
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.