Predicting tuberculosis progression in young children with and without HIV
Official title: PROgression of Tuberculosis infECTion in young children living with and without HIV: the PROTECT study
Funded at University of California-Irvine · NIH-11488586 · Data updated 2026-11-12
This project will look for blood markers that show which young children with or without HIV are most likely to develop active tuberculosis so they can get earlier prevention or treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $100,473 |
| NIH project number | 3R01AI175312-04S2 |
| Project ID | NIH-11488586 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are young children—particularly under age 5—who have recent TB exposure or known M. tuberculosis infection, including those living with HIV.
✕Less likely to help
Children without any history of TB exposure or infection and most adults are unlikely to benefit directly from this specific pediatric-focused project.
What this research studies
Researchers will analyze stored blood and other samples from children in Uganda, South Africa, the Gambia, and Vietnam, including samples collected over time from children who later developed TB. They will compare children who stayed healthy to those who progressed to TB to find host immune markers that appear before disease. The team aims to identify a small set of markers that meet WHO accuracy goals and could be turned into a simple point-of-care test. The work includes children with and without HIV to make sure findings apply to those at highest risk.
Why it matters
Potential benefit: If successful, this could help identify high-risk children earlier so they can receive preventive treatment and avoid severe TB or death.
How similar studies have gone: Some adult and older-child biomarker studies have shown promising signals but few have met WHO targets, so a pediatric-focused biomarker approach is relatively novel and needed.
Where this research is happening
-
University of California-Irvine
Irvine, United States Active
Researchers
- Principal investigator: Cattamanchi, Adithya — University of California-Irvine
- Study coordinator: Cattamanchi, Adithya
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.