Brazil Tuberculosis (TB) Network for Patients and Contacts
Official title: Regional Prospective Observational Research in Tuberculosis (RePORT) – Brazil Network
Funded at Vanderbilt University Medical Center · NIH-11468136 · Data updated 2026-11-12
This project follows people with TB and their close contacts in Brazil to learn what helps with diagnosis, treatment, and prevention.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | January 2, 2023 |
| Project end | December 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $472,748 |
| NIH project number | 3U01AI172064-04S1 |
| Project ID | NIH-11468136 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are people diagnosed with pulmonary TB and their close household or community contacts, including those with HIV or diabetes who receive care at participating Brazilian sites.
✕Less likely to help
People who do not have TB, are not close contacts, or who live far from participating clinics in Brazil are unlikely to be eligible or receive direct benefit.
What this research studies
If you have TB or are a close contact of someone with TB, this network enrolls people at clinics in Brazil and collects clinical information, blood and sputum samples, and other data over time. Researchers use stored specimens plus new genomic and transcriptomic testing to look for markers of infection, disease progression, drug resistance, and treatment outcomes. The project builds on an earlier phase that enrolled over a thousand TB patients and nearly two thousand contacts and links efforts with other international RePORT sites. Participation may include clinical visits, sample collection, and follow-up over months to years.
Why it matters
Potential benefit: If successful, this work could improve how TB is diagnosed, treated, and prevented for people in Brazil and beyond.
How similar studies have gone: Phase 1 of RePORT-Brazil and related RePORT networks have already produced data and findings on TB risk factors, diagnostics, and outcomes, providing a strong foundation for this phase.
Where this research is happening
-
Vanderbilt University Medical Center
Nashville, United States Active
Researchers
- Principal investigator: Sterling, Timothy R — Vanderbilt University Medical Center
- Study coordinator: Sterling, Timothy R
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.