Coach Mpilo peer support for men with TB and HIV

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This project will adapt the Coach Mpilo peer-support model for men initiating TB treatment and for men with TB/HIV co-infection, creating CM-TB and CM-TB/HIV versions. Using the ADAPT-IIT model and a mixed-methods approach, investigators will conduct interviews, role simulations, and a small pre-test/pilot to refine the intervention. Subsequent implementation will enroll men initiating or re-initiating TB therapy in Buffalo City Metro (BCM) Health Districts to measure feasibility and collect secondary outcomes on TB treatment completion and HIV viral suppression. Findings will inform a later Hybrid Type I implementation-effectiveness effort.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Aim 2: 1) men; 2) aged ≥18 years; 3) newly initiating (i.e., treatment naive) or re-initiating TBT after being loss-from-care per South African national guidelines; 4) live in BCM Health Districts; and 5) provide written informed consent.

Aim 3: 1) men; 2) aged ≥18 years; 3) newly initiating (i.e., treatment naive) or re-initiating TBT after being loss-from-care per South African national guidelines; 4) HIV-positive; 5) Not on ART, 6) live in BCM Health Districts; and 7) provide written informed consent.

Exclusion Criteria:

Aim 2: 1) Not a man; 2) aged \< 18 years; 3) not initiating (i.e., treatment naive) or not re-initiating TBT after being loss-from-care per South African national guidelines; 4) not live in BCM Health Districts; and 5) cannot provide written informed consent.

Aim 3: 1) Not a man; 2) aged \< 18 years; 3) not initiating (i.e., treatment naive) or not re-initiating TBT after being loss-from-care per South African national guidelines; 4) not HIV-positive; 5) on ART, 6) not live in BCM Health Districts; and 7) cannot provide written informed consent.

Where it's running

• Desmond Tutu Health Foundation
  East London, South Africa Recruiting

Study contacts

• Study coordinator: Joseph Daniels
• Email: Joseph.A.Daniels@asu.edu
• Phone: 206-459-5777

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Reexamining how asymptomatic tuberculosis spreads

  This project will test whether people with asymptomatic tuberculosis—particularly adults living with HIV—can pass TB to their household and close contacts.

  Recruiting Barcelona Institute for Global Health · Manhiça, Maputo Province · NCT07312266

• Validation of Treatment Decision Algorithms for Childhood Tuberculosis

  This study is testing a new way to help doctors in Zambia and Mozambique make better decisions for screening and treating tuberculosis in children under 15 years old.

  Recruiting at 29 sites University of Zambia · Chingola, Copperbelt and 28 other locations · NCT06593080

• Dolutegravir plus lamivudine two-drug HIV treatment for people starting rifampin-based TB therapy

  This will test whether a two-drug HIV regimen (dolutegravir plus lamivudine), given either twice daily or as Dovato in the morning plus extra dolutegravir in the evening, works and is safe for ART‑naïve people with HIV who are receiving rifampin-based tuberculosis treatment compared with standard three‑drug therapy.

  Recruiting at 5 sites Phase 3 Johns Hopkins University · Manaus, Amazonas and 4 other locations · NCT06497465

• Doxycycline added to standard treatment for central nervous system tuberculosis

  This trial tests whether adding doxycycline to standard anti‑TB therapy and corticosteroids helps adults with central nervous system tuberculosis live longer or have less severe neurological disability.

  Recruiting at 5 sites Phase 2 National University Hospital, Singapore · Medan, Medan and 5 other locations · NCT06446245

• Peer-led TB and HIV education and adherence counseling in Uganda

  This trial will test whether peer-led TB education and counseling helps adults with tuberculosis (with or without HIV) stick to treatment and have better health outcomes.

  Recruiting Yale University · Kampala · NCT05917210

• Long-term study of HIV patients in rural India

  This study looks at how HIV affects people living in rural India over time to see how well different treatments work and to understand the disease better.

  Recruiting Rural Development Trust Hospital · Battalapalli, Andhra Pradesh · NCT02454569

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.