Screening for latent tuberculosis in school contacts of active patients

Active Screening of Latent Tuberculosis Infection in School Contacts of Active Tuberculosis Patients

This study is testing how common tuberculosis infection is among students aged 13 and older who have been in close contact with active tuberculosis patients to improve screening methods in schools.

Quick facts

• Study type: Observational
• Enrollment: 31440 (estimated)
• Ages: 13 Years and up
• Sex: All
• Sponsor: Huashan Hospital (Academic / other)
• Locations: 44 sites (Zunyi, Guiyang and 43 other locations)
• Trial ID: NCT06033807 on ClinicalTrials.gov

What this trial studies

This observational study aims to assess the prevalence of Mycobacterium tuberculosis infection among students who have been in close contact with active tuberculosis patients. It will evaluate risk factors associated with tuberculosis infection and conduct a health economic analysis of the screening strategy using the QuantiFERON-TB Gold test. The study focuses on students aged 13 and older from junior middle school to university who have been in close contact with active cases. The findings could help improve screening strategies in educational settings.

Who should consider this trial

Good fit: Ideal candidates for this study are students aged 13 and older who have had close contact with active tuberculosis patients.

Not a fit: Patients currently diagnosed with active tuberculosis or those who have completed treatment for active or latent tuberculosis will not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved screening and early detection of latent tuberculosis infection among school contacts, potentially reducing the spread of the disease.

How similar studies have performed: Other studies have shown success in screening strategies for tuberculosis in similar populations, indicating that this approach is supported by prior research.

Eligibility criteria

Inclusion Criteria:

* 13 years old or above;
* Students in junior middle school, high school and university;
* Close contact of school active tuberculosis case (e.g. in the same classroom, in the same dormitory);
* Himself/herself (together with his/her guardian for age under 18 years old) willing to participate in trial and sign informed consent.

Exclusion Criteria:

* Current clinical or sputum culture confirmed active tuberculosis
* Have completed a full course of treatment for ATB or LTBI

Where this trial is running

Zunyi, Guiyang and 43 other locations

• Xinpu New Area Center of Disease Control — Zunyi, Guiyang, China (Recruiting)
• Dafang Center for Disease Control and Prevention — Bijie, Guizhou, China (Recruiting)
• Qixingguan Center for Disease Control and Prevention — Bijie, Guizhou, China (Recruiting)
• Nayong Center for Disease Control and Prevention — Bijie, Guizhou, China (Recruiting)
• Hezhang Center for Disease Control — Bijie, Guizhou, China (Recruiting)
• Jinsha Center for Disease Control — Bijie, Guizhou, China (Recruiting)
• Qianxi Center of Disease Control — Bijie, Guizhou, China (Recruiting)
• Weining Center of Disease Control — Bijie, Guizhou, China (Recruiting)
• Zhijin Center of Disease Control — Bijie, Guizhou, China (Recruiting)
• Liping Center for Disease Control and Prevention — Linping, Guizhou, China (Recruiting)
• Liuzhi Special District Center of Disease Control — Liupanshui, Guizhou, China (Recruiting)
• Panzhou Center of Disease Control — Liupanshui, Guizhou, China (Recruiting)
• Shuicheng District Center of Disease Control — Liupanshui, Guizhou, China (Recruiting)
• Cengong Center of Disease Control — Qiandongnan Miao and Dong Autonomous Prefecture, Guizhou, China (Recruiting)
• Congjiang Ceter of Disease Control — Qiandongnan Miao and Dong Autonomous Prefecture, Guizhou, China (Recruiting)
• Danzhai Center of Disease Control — Qiandongnan Miao and Dong Autonomous Prefecture, Guizhou, China (Recruiting)
• Huangping Center of Disease Control — Qiandongnan Miao and Dong Autonomous Prefecture, Guizhou, China (Recruiting)
• Jianhe Center of Disease Control — Qiandongnan Miao and Dong Autonomous Prefecture, Guizhou, China (Recruiting)
• Jinping Center of Disease Control — Qiandongnan Miao and Dong Autonomous Prefecture, Guizhou, China (Recruiting)
• Kaili Center of Disease Control — Qiandongnan Miao and Dong Autonomous Prefecture, Guizhou, China (Recruiting)
• Leishan Center of Disease Control — Qiandongnan Miao and Dong Autonomous Prefecture, Guizhou, China (Recruiting)
• Majiang Center of Disease Control — Qiandongnan Miao and Dong Autonomous Prefecture, Guizhou, China (Recruiting)
• Rongjiang Center of Disease Control — Qiandongnan Miao and Dong Autonomous Prefecture, Guizhou, China (Recruiting)
• Sansui Center of Disease Control — Qiandongnan Miao and Dong Autonomous Prefecture, Guizhou, China (Recruiting)
• Shibing Center of Disease Control — Qiandongnan Miao and Dong Autonomous Prefecture, Guizhou, China (Recruiting)
• Taijiang Center of Disease Control — Qiandongnan Miao and Dong Autonomous Prefecture, Guizhou, China (Recruiting)
• Tianzhu Center of Disease Control — Qiandongnan Miao and Dong Autonomous Prefecture, Guizhou, China (Recruiting)
• Zhenyuan Center of Disease Control — Qiandongnan Miao and Dong Autonomous Prefecture, Guizhou, China (Recruiting)
• Qingzhen Center for Disease Control and Prevention — Qingzhen, Guizhou, China (Recruiting)
• Bozhou District Center of Disease Control — Zunyi, Guizhou, China (Recruiting)
• Chishui Center of Disease Control — Zunyi, Guizhou, China (Recruiting)
• Daozhen Center of Disease Control — Zunyi, Guizhou, China (Recruiting)
• Fenggang Center of Disease Control — Zunyi, Guizhou, China (Recruiting)
• Honghuagang District Center of Disease Control — Zunyi, Guizhou, China (Recruiting)
• Huichuan District Center of Disease Control — Zunyi, Guizhou, China (Recruiting)
• Meitan Center of Disease Control — Zunyi, Guizhou, China (Recruiting)
• Renhuai Center of Disease Control — Zunyi, Guizhou, China (Recruiting)
• Suiyang Center of Disease Control — Zunyi, Guizhou, China (Recruiting)
• Tongzi Center of Disease Control — Zunyi, Guizhou, China (Recruiting)
• Wuchuan Center of Disease Control — Zunyi, Guizhou, China (Recruiting)
• Xishui Center of Disease Control — Zunyi, Guizhou, China (Recruiting)
• Yuqing Center of Disease Control — Zunyi, Guizhou, China (Recruiting)
• Zhengan Center of Disease Control — Zunyi, Guizhou, China (Recruiting)
• Dalian Public Health Clinical Center — Dalian, Liaoning, China (Recruiting)

Study contacts

• Principal investigator: Wenhong Zhang, PhD — Huashan Hospital
• Study coordinator: Qiaoling Ruan, PhD

Conditions Tuberculosis; Latent Tuberculosis Infection; latent tuberculosis; active screening