Understanding lung problems that linger after TB treatment in Peru
Official title: Host- and pathogen-specific risk factors for post-tuberculosis lung disease among people successfully treated for TB in Lima, Peru: Beat-PTLD
Funded at Harvard Medical School · NIH-11511777 · Data updated 2026-11-12
A study following people who were treated for TB in Lima, Peru to see what kinds of long-lasting lung problems they have and what factors put them at risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard Medical School NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 20, 2025 |
| Project end | June 30, 2030 |
| Funding year | 2026 |
| Award (this year) | $607,955 |
| NIH project number | 3R01HL178712-02S1 |
| Project ID | NIH-11511777 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults previously treated for TB, especially those in Lima, Peru, and those with risk factors or persistent respiratory symptoms.
✕Less likely to help
Individuals without prior TB or those without any signs of lung impairment may see minimal direct benefit.
What this research studies
This project will re-contact 1,000 individuals who survived TB and 291 community controls to measure lung function 2-3 years after TB treatment. Researchers will collect medical history, perform lung tests, and examine factors like age, prior health, and exposure to infections to identify who develops post-TB lung disease and why. The goal is to find practical ways to screen high-risk people and guide interventions that improve breathing and quality of life after TB. The study leverages an existing cohort to build a clearer picture of PTLD in a real-world setting. Results could inform future care recommendations for TB survivors in Peru and beyond.
Why it matters
Potential benefit: If successful, the study could lead to earlier identification and better management of long-term lung problems after TB.
How similar studies have gone: Previous research has established that PTLD is a real problem; this study aims to better quantify risk factors and screening approaches in a new population.
Where this research is happening
-
Harvard Medical School
Boston, United States Active
Researchers
- Principal investigator: Mitnick, Carole D. — Harvard Medical School
- Study coordinator: Mitnick, Carole D.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.