Improving tuberculosis case detection in low-resource settings

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to enhance the detection of tuberculosis (TB) in primary healthcare centers in low-resource settings by comparing two diagnostic procedures: the Enhanced Usual Diagnostic Procedure (EUDP) and the Optimized Diagnostic Procedure (ODP). Conducted in Guinea Bissau and Ethiopia, the trial will assess the diagnostic yield of active TB within ten days and the number of patients treated for TB within two weeks. It will also evaluate the effectiveness of various diagnostic methods, including the use of Oxford Nanopore sequencing for detecting TB and its resistance patterns. The goal is to improve case detection rates, initiate prompt treatment, and ultimately reduce TB transmission in the community.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* ≥15 years old
* presumed TB with cough, sputum production, and/or weight loss of any duration

Exclusion Criteria:

* TB treatment within the past year.
* Cerebral disturbances impairing the ability to give informed consent or follow the treatment regime.

Where it's running

• Gondar University
  Gonder, Ethiopia Recruiting
• Projecto Saude de Bandim
  Bissau, Guinea-Bissau Recruiting

Study contacts

• Study coordinator: Frauke Rudolf
• Email: frauke.rudolf@au.dk
• Phone: 51372359

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.