Identifying biomarkers that predict TB disease risk in children with HIV
Official title: Identifying correlates of risk for future tuberculosis disease progression in children (INTREPID)
Funded at Stellenbosch University · NIH-11519036 · Data updated 2026-11-12
Researchers will study stored samples from young children, including those with HIV, to find biological markers that signal who might develop TB or respond to treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stellenbosch University NIH-funded |
| Lab location | 1 site (Stellenbosch, SOUTH AFRICA) |
| Project start | May 5, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $24,441 |
| NIH project number | 3R01AI175235-04S2 |
| Project ID | NIH-11519036 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children exposed to TB, especially those who are HIV-infected or have HIV exposure, and who are part of longitudinal TB studies.
✕Less likely to help
Children without TB exposure or HIV infection may not benefit from this biomarker-focused approach.
What this research studies
This project will analyze existing samples from children in TB studies using blood-based and molecular profiling techniques to find signatures linked to progression to TB disease and how well treatment works. It will combine data from transcriptomics, proteomics, metabolomics, and antibody profiles with information on HIV status, co-infections, and clinical factors. The goal is to identify biomarker patterns that can guide targeted TB preventive therapy and improve patient care. The work will be conducted in collaboration with clinical teams in the United States and globally, leveraging stored samples and longitudinal data. Outcomes could directly influence how clinicians monitor and protect children exposed to TB.
Why it matters
Potential benefit: If successful, this research could enable earlier identification of children at highest risk for TB and tailor preventive treatment and monitoring accordingly.
How similar studies have gone: Previous biomarker studies in TB have identified signatures associated with disease risk, but this project aims to integrate multiple omics to improve predictive power in children and HIV contexts.
Where this research is happening
-
Stellenbosch University
Stellenbosch, South Africa Active
Researchers
- Principal investigator: Seddon, James Alexander — Stellenbosch University
- Study coordinator: Seddon, James Alexander
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.