Short-Course TB Prevention for People with HIV: Better Adherence with Facilitated 3HP Delivery
Official title: Options for Delivery of Short-Course Tuberculosis Preventive Therapy: The 3HP Options Trial
Funded at University of California-Irvine · NIH-11549398 · Data updated 2026-11-12
A trial tests easier, supportive ways to help people with HIV complete a short, weekly TB preventive treatment (3HP).
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project start | August 1, 2018 |
| Project end | July 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $85,262 |
| NIH project number | 3R01HL144406-08S2 |
| Project ID | NIH-11549398 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults living with HIV who are eligible for 12 weeks of 3HP TB preventive therapy.
✕Less likely to help
People not receiving 3HP or those without HIV may not benefit from this specific strategy.
What this research studies
If you have HIV, this study looks at whether adding helpful reminders, friendly counseling, and easy self-checks makes it more likely you’ll finish the 12-week 3HP TB preventive therapy. The researchers compare a simplified, facilitated self-administered approach to standard self-administration across multiple HIV clinics. The goal is to see if these supports boost completion rates and reduce health-system costs while keeping safety in mind. The study builds on earlier findings showing high completion with facilitated taming of barriers, now testing applicability across diverse clinical settings.
Why it matters
Potential benefit: If successful, the approach could make it easier for people with HIV to complete TB preventive therapy, reducing TB risk and possibly lowering clinic costs.
How similar studies have gone: Prior single-center results suggested high completion with facilitated self-administered therapy, and this trial tests broader implementation.
Where this research is happening
-
University of California-Irvine
Irvine, United States Active
Researchers
- Principal investigator: Cattamanchi, Adithya — University of California-Irvine
- Study coordinator: Cattamanchi, Adithya
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.