Coronary disease and immune activation in people with HIV and tuberculosis coinfection
Official title: Coronary Atherosclerosis and Immune Activation in HIV and Tuberculosis Infection
Funded at Emory University · NIH-11618831 · Data updated 2026-11-12
This research looks at how having HIV and latent tuberculosis together might raise the risk of heart disease, and what immune changes are involved.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | August 2, 2022 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $438,482 |
| NIH project number | 7R01HL156779-05 |
| Project ID | NIH-11618831 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults living with HIV, with or without latent tuberculosis infection, who may have or be at risk for heart disease.
✕Less likely to help
People without HIV or latent TB infection, or those without cardiovascular risk may not directly benefit.
What this research studies
People living with HIV may have higher heart-disease risk, possibly driven by immune activation. This project will compare HIV patients with and without latent TB infection to understand how their arteries and heart plaques differ. It includes human studies and potentially translational work to link immune markers with plaque biology. Animal studies and human data will be used to explore how latent TB affects heart disease risk in the context of HIV.
Why it matters
Potential benefit: Findings could clarify why some people with HIV and latent TB have more heart disease and guide strategies to reduce risk.
How similar studies have gone: Preliminary human data in HIV-uninfected individuals link LTBI with higher heart disease markers, supporting further study in HIV.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Huaman Joo, Moises Arturo — Emory University
- Study coordinator: Huaman Joo, Moises Arturo
Related research
Other NIH-funded projects on the same topics.
-
Heart artery disease in people with HIV and latent tuberculosis
This project looks at whether people living with HIV who also have latent tuberculosis develop more artery plaque and heart disease than those without tuberculosis.
-
Investigating heart disease risk in people with HIV and tuberculosis
This study is looking at how having both HIV and tuberculosis might increase the risk of heart problems, especially in people living in Lima, Peru, and aims to find out how these infections affect heart health.
-
Pulmonary rehabilitation to reduce breathing problems after tuberculosis
A program of guided exercise and breathing training to help adults who have recovered from TB breathe better and feel healthier.
-
Pulmonary rehab to reduce breathing troubles after TB
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-
Air pollution and tuberculosis spread in Kampala, Uganda
This project looks at whether dirty air from PM2.5 particles makes tuberculosis more likely to spread within urban slum households in Kampala, Uganda.
-
Air pollution and TB spread in Ugandan urban slums
This project explores whether exposure to air pollution makes tuberculosis more likely to spread within households in a crowded Ugandan slum.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.