Understanding TB Infection Risks in Health Workers

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on health workers in Cape Town, South Africa, who are at high risk for tuberculosis (TB) infection. It aims to evaluate immune responses to TB through frequent testing every three months over a year, using a combination of novel assays. By characterizing the dynamic immune responses at the time of initial infection, the study seeks to improve understanding of TB infection and identify individuals at risk of developing active TB disease. The findings will help inform targeted preventive strategies for those exposed to TB.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* ≥18 years old
* Health worker
* Able to provide informed consent

Exclusion Criteria:

* Prior history of TB or known prior positive IGRA
* Current or prior history of taking anti-TB treatment

Where it's running

• Stellenbosch University
  Cape Town, South Africa Recruiting

Study contacts

• Principal investigator: Ruvandhi Nathavitharana, MBBS MPH — Beth Israel Deaconess Medical Center
• Study coordinator: Ruvandhi Nathavitharana, MBBS MPH
• Email: rnathavi@bidmc.harvard.edu
• Phone: +16467152601

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.