Condition

Acute Coronary Syndrome clinical trials and research

• 70Clinical trials
• 7NIH research projects
• 32Countries

Newest Acute Coronary Syndrome clinical trials

All recruiting trials (70)

• Common femoral vein-to-artery diameter ratio to detect elevated LVEDP

  Researchers test whether the ratio of the common femoral vein to artery diameters, measured by ultrasound, can flag elevated LV end-diastolic pressure in patients having coronary angiography.

  Recruiting Burapha University · Chon Buri · NCT07866859

• Intrahospital flu vaccine for adults with high cardiovascular risk when admitted for ACS or heart failure

  This study tests whether offering a flu vaccine at the bedside during a hospital stay, along with counseling, increases vaccination rates for adults with acute coronary syndrome or heart failure who are at high cardiovascular risk.

  Recruiting at 2 sites University Hospital of Cologne · Cologne and 1 other locations · NCT07721649

• Digital lifestyle platform after rehabilitation to support self-management

  A digital, patient-facing platform is being tested to see if people who recently finished inpatient rehabilitation will use it and benefit from personalized lifestyle guidance at home.

  Recruiting at 2 sites Insel Gruppe AG, University Hospital Bern · Bern, Canton of Bern and 1 other locations · NCT07597031

• AI-driven Medipixel fractional flow reserve to guide PCI

  This test checks whether an AI-based, angiography-derived Medipixel FFR method can guide PCI as safely and effectively as standard invasive pressure-wire FFR in adults with coronary artery disease.

  Recruiting at 23 sites Samsung Medical Center · Seoul, Select State and 22 other locations · NCT07329699

• Freesolve resorbable magnesium scaffold vs. Xience stent for up to two new heart artery lesions

  This trial tests whether the Freesolve resorbable magnesium scaffold works as well as the Xience drug-eluting stent for treating up to two new coronary artery lesions in adults.

  Recruiting at 3 sites Teleflex · Washington D.C., District of Columbia and 2 other locations · NCT07258290

• AI-assisted interpretation of chest pain CT in the emergency department

  A pragmatic randomized trial tests whether an AI tool (Angiomics) helps emergency physicians interpret coronary CT angiography in adults with acute chest pain.

  Recruiting Yonsei University · Seoul · NCT07235657

• One-month vessel healing after BioFreedom polymer-free drug-coated stent versus Xience drug-eluting stent in heart attack patients with high bleeding risk

  We'll use very detailed optical imaging to see if the polymer-free BioFreedom stent leads to faster or better vessel healing than the Xience stent in people with a recent heart attack who are at high bleeding risk.

  Recruiting China National Center for Cardiovascular Diseases · Beijing, Beijing Municipality · NCT07230847

• Thrombus aspiration and OCT comparison in acute coronary syndromes

  This project will test whether material suctioned from clots during PCI matches OCT imaging findings in people with acute coronary syndrome (STEMI or NSTEMI).

  Recruiting Fujita Health University · Toyoake, Aichi-ken · NCT07151976

• Early in-hospital start of inclisiran for people with acute coronary syndrome

  This study tests whether giving inclisiran soon after hospital admission helps people with acute coronary syndrome when added to standard care compared with a placebo.

  Recruiting at 27 sites Phase 3 Novartis · Capital Federal, Buenos Aires and 68 other locations · NCT07102628

• Single polypill combining aspirin, a P2Y12 inhibitor, and a statin after acute coronary syndrome

  This trial tests whether giving adults who had an acute coronary syndrome a single combined pill with aspirin, a P2Y12 inhibitor, and a high-intensity statin helps them stick to their medicines and lowers complications after discharge.

  Recruiting at 4 sites Phase 2 University of Texas Southwestern Medical Center · Dallas, Texas and 3 other locations · NCT07032389

• Analyzing Blood Changes in Patients with Acute Coronary Syndrome

  This study looks at blood samples from patients with acute coronary syndrome to see how their blood factors differ from those without heart disease, hoping to find clues about the condition's outlook.

  Recruiting Second Affiliated Hospital of Wenzhou Medical University · Lishui, Zhejiang · NCT06955143

• Using C-reactive protein to albumin ratio to predict heart events in acute coronary syndrome

  This study is testing if a blood test measuring the C-reactive protein to albumin ratio can help predict serious heart problems in patients with acute coronary syndrome while they are in the hospital.

  Recruiting Sohag University · Sohag · NCT06673381

• Comparing two types of drug-coated stents for patients at high bleeding risk

  This study is testing if a new type of drug-coated stent is just as good and safe as a standard one for people with coronary artery disease who are at high risk of bleeding.

  Recruiting at 6 sites Biosensors Europe SA · Johor Bahru, Johor and 5 other locations · NCT06657326

• Optimizing long-term prevention of cardiovascular disease after acute coronary syndrome

  This study tests if starting a complete medication plan right away for people hospitalized with heart disease can help prevent serious heart problems better than the usual gradual approach.

  Recruiting Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Amsterdam · NCT06637657

• Using cardiac MRI before invasive coronary angiography for suspected NSTEMI patients

  This study is testing if doing a cardiac MRI before an invasive heart procedure can help doctors better diagnose NSTEMI in patients and possibly reduce the need for that procedure.

  Recruiting Region Stockholm · Stockholm, Sweden · NCT06566625

• Evaluating colchicine therapy after heart procedures

  This study is testing if adding a low dose of colchicine to a common heart medication can help people who have had heart procedures avoid serious heart problems in the year after their treatment.

  Recruiting at 9 sites Phase 4 CHA University · Seongnam-si, Gyeonggi-do and 8 other locations · NCT06543082

• Single versus dual antiplatelet therapy after drug-coated balloon angioplasty in elderly or high-bleeding-risk patients

  This study tests whether taking one antiplatelet medicine is as safe and causes less bleeding than taking two medicines for people aged 75 or older, or adults at high bleeding risk, after drug-coated balloon angioplasty for coronary artery disease.

  Recruiting Fondazione Ricerca e Innovazione Cardiovascolare ETS · Milan, MI · NCT06535568

• Heart registry for patients after coronary interventions in South East Netherlands

  This study is creating a registry to help doctors better understand and treat patients in South East Netherlands who have had heart procedures, aiming to reduce their risk of future heart problems.

  Recruiting at 4 sites Radboud University Medical Center · Heerlen, Limburg and 3 other locations · NCT06512493

• Evaluating a new device for heart condition diagnosis

  This study is testing a new device to see if it can help doctors better diagnose heart problems in patients who are already scheduled for heart procedures.

  Recruiting at 2 sites SB Technology, Inc. · Rochester, Minnesota and 1 other locations · NCT06481943

• Registry of genetic, molecular, and diversity differences in women with acute coronary syndrome

  This project will collect clinical, genetic, biochemical, and molecular information from women with acute coronary syndrome across Italy to see if differences by age, ethnicity, or disease type relate to presentation and outcomes.

  Recruiting at 4 sites IRCCS San Raffaele · Milan, Italy Milan and 3 other locations · NCT06441942

• Using AI to predict acute coronary syndrome from white blood cell data

  This study is testing if artificial intelligence can predict acute coronary syndrome by looking at white blood cell data in adults, comparing it to standard blood tests.

  Recruiting RobotDreams GmbH · Graz, Styria / Steiermark · NCT06384846

• Resilience training for patients with heart disease

  This study tests a resilience training program to see if it helps heart disease patients cope better with stress and improve their overall quality of life.

  Recruiting Pensionsversicherungsanstalt · Bad Tatzmannsdorf, Burgenland · NCT06332859

• Understanding sex hormones and inflammation in heart disease

  This study looks at how sex hormones and inflammation affect heart disease in women to better understand their unique risks and improve treatment.

  Recruiting Queen Mary University of London · London · NCT06327984

• Online therapy for anxiety after heart issues

  This study is testing an online therapy program to see if it can help people recovering from heart issues feel less anxious and improve their quality of life.

  Recruiting Karolinska Institutet · Stockholm · NCT06298864

• Effects of Dapagliflozin on Heart Health in Patients with Acute Coronary Syndromes

  This study is testing if dapagliflozin, a diabetes medication, can improve heart health in people who have just had a heart attack.

  Recruiting Phase 2/3 University of Sao Paulo · São Paulo, São Paulo · NCT06286878

• Evaluating the impact of angiography-based FFR after heart procedures

  This study is trying to see if measuring blood flow in heart arteries after a heart procedure can help predict serious heart problems and improve patients' quality of life.

  Recruiting Medical University of Warsaw · Warsaw · NCT06255678

• OPT-CAD–guided timing for switching to a P2Y12 inhibitor alone after PCI in acute coronary syndrome

  This trial will try using the OPT-CAD score to decide whether people with acute coronary syndrome can switch from dual antiplatelet therapy to a single P2Y12 drug after 1 or 3 months following stent placement.

  Recruiting Shenyang Northern Hospital · Shenyang, Liaoning · NCT06216821

• Using low-dose colchicine to treat acute coronary syndromes

  This study tests if adding low-dose colchicine to standard treatment can help people with acute coronary syndromes avoid serious heart problems.

  Recruiting Beijing Anzhen Hospital · Beijing, Beijing Municipality · NCT06215989

• Registry of patients with acute cardiovascular diseases in Naples

  This study looks at how patients with serious heart problems are treated and what happens to them while they are in the hospital and after they go home.

  Recruiting Federico II University · Naples · NCT06162247

• Registry for patients with acute coronary syndrome

  This study is collecting information about patients with acute coronary syndrome at the University Hospital of Heidelberg to better understand their characteristics and treatment.

  Recruiting University Hospital Heidelberg · Heidelberg, Baden-Wurttemberg · NCT06128317

• Early Initiation of PCSK9 Inhibitor Tafolecimab in ACS Patients Undergoing PCI

  This trial tests starting Tafolecimab early in people with acute coronary syndrome who are having PCI to lower bad cholesterol quickly and see if it reduces heart problems after discharge.

  Recruiting at 2 sites Phase 4 China National Center for Cardiovascular Diseases · Beijing, Beijing Municipality and 1 other locations · NCT06096909

• Using a new imaging agent to detect inflamed plaque in heart and brain patients

  This study is testing a new imaging agent to see if it can help spot inflamed plaque in patients who have recently had a heart attack or stroke.

  Recruiting Ottawa Heart Institute Research Corporation · Ottawa, Ontario · NCT06091319

• Registry for patients with heart conditions and treatments

  This study is collecting information from patients with heart conditions who have received certain treatments to see how they are doing over time and improve care for these conditions.

  Recruiting University Hospital Dubrava · Zagreb · NCT06090591

• Using music to reduce anxiety in patients with acute coronary syndrome during emergency care

  This study is testing if listening to music can help reduce anxiety in patients with acute coronary syndrome while they wait for emergency care.

  Recruiting Centre Hospitalier Universitaire de la Réunion · Saint-Pierre, Île de La Réunion · NCT06017947

• Using continuous glucose monitoring to predict outcomes in acute coronary syndrome

  This study is testing if continuous glucose monitoring can help doctors predict outcomes for patients with acute coronary syndrome by looking at their blood sugar levels.

  Recruiting at 9 sites University Hospital, Montpellier · Béziers and 8 other locations · NCT06014112

• Genotype-guided clopidogrel treatment for heart patients

  This study is testing if giving heart patients a blood thinner based on their genes can help them avoid complications better than the usual treatment after a heart procedure.

  Recruiting Phase 2 St. Antonius Hospital · Nieuwegein, Utrecht · NCT05926271

• Dalcetrapib's effect on heart risk in patients with recent heart issues and specific genetics

  This study is testing if a new drug called Dalcetrapib can lower heart risks in people who have recently had heart issues and have a specific genetic makeup.

  Recruiting at 157 sites Phase 3 DalCor Pharmaceuticals · Alexander City, Alabama and 230 other locations · NCT05918861

• Using magnetocardiography to identify heart attacks

  This study is testing if a new noninvasive heart scan method can help doctors better identify heart attacks in people with chest pain and healthy volunteers.

  Recruiting Qilu Hospital of Shandong University · Jinan, Shandong · NCT05896826

• Decision support for patients with chest pain in emergency settings

  This study is testing a new system that uses machine learning to help emergency medical teams better understand and treat patients with chest pain.

  Recruiting at 3 sites Vastra Gotaland Region · Kungsbacka, Region Halland and 2 other locations · NCT05767619

• Investigating risk factors in patients with acute coronary syndrome undergoing a procedure

  This study is trying to find out what risk factors affect patients with acute coronary syndrome who are having a heart procedure and how these factors relate to their health outcomes over two years.

  Recruiting Jinan Central Hospital · Jinan, Shandong · NCT05719545

• Guiding NOAC therapy for patients with acute coronary syndrome after heart procedures

  This study is testing a new combination of heart medications to see if it can help people with acute coronary syndrome avoid serious heart problems without causing more bleeding than standard treatment.

  Recruiting Phase 4 China National Center for Cardiovascular Diseases · Beijing, Beijing Municipality · NCT05638867

• Using doxycycline to improve lung function in tuberculosis patients

  This study is testing if adding doxycycline to the standard treatment for tuberculosis can help improve lung function and reduce damage in patients with lung infections.

  Recruiting at 3 sites Phase 3 National University Hospital, Singapore · Kota Kinabalu, Sabah and 5 other locations · NCT05473520

• Colchicine treatment for heart attack recovery

  This study tests if colchicine can help people recovering from a heart attack by reducing heart damage and improving their recovery.

  Recruiting Phase 2 Pontificia Universidad Catolica de Chile · Santiago, Santiago Metropolitan · NCT05472337

• Comparing two methods for guiding heart procedures in patients with coronary artery disease

  This study is testing if using a new type of pressure tool for heart procedures can work just as well as the traditional method for patients with coronary artery disease.

  Recruiting at 24 sites Phase 4 CoreAalst BV · Aalst, Oost-Vlaanderen and 28 other locations · NCT05437900

• Assessing heart disease risk using carotid ultrasound and stress tests

  This study is testing if combining a special ultrasound of the neck with stress tests can better identify people at risk for serious heart problems over the next three years.

  Recruiting at 5 sites Queen's University · Calgary, Alberta and 5 other locations · NCT05416385

• Evaluation of the AngelMed Guardian® System for patients with Acute Coronary Syndrome

  This study is testing how well the AngelMed Guardian® System works for people who have had acute coronary syndrome and if healthcare providers are properly trained to use it.

  Recruiting at 12 sites Angel Medical Systems · Glendale, Arizona and 17 other locations · NCT05412927

• Improving positive emotions and physical activity after heart events

  This study is trying out a new program that combines positive thinking and motivation to help people recovering from heart events get more active and feel better compared to regular care.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT05412862

• Guideline-based lipid lowering approach in Asia-Pacific patients

  This study tests if a special cholesterol management plan helps people in the hospital for a heart attack feel better compared to standard care.

  Recruiting at 11 sites Monash University · Wollongong, New South Wales and 21 other locations · NCT05325034

• Comparing two types of stents for heart patients on short-term medication

  This study is testing whether a new type of heart stent without a polymer works better than a biodegradable one for patients with acute coronary syndrome who are on short-term medication.

  Recruiting Yonsei University · Seoul · NCT05305482

• Aggressive smoking cessation for patients with heart conditions

  This study is testing if a stronger smoking cessation program using both medication and counseling can help people with heart conditions quit smoking more effectively than just medication and counseling alone.

  Recruiting at 13 sites Phase 3 Sir Mortimer B. Davis - Jewish General Hospital · New Westminster, British Columbia and 12 other locations · NCT05257629

• Registry collecting data on patients undergoing heart artery procedures

  This study is collecting information from patients who are having heart artery procedures to see how they do during and after their treatment.

  Recruiting Federico II University · Naples · NCT05248165

• Survey of ALDH Gene Family in Patients with Peripheral Artery Disease or Heart Issues

  This study is trying to see how common a specific gene deficiency is in people with heart problems or poor circulation, especially in the Asian community, to understand its impact on their health.

  Recruiting Chimei Medical Center · Tainan · NCT05078814

• Sequential use of ticagrelor and clopidogrel after heart procedures

  This study is testing if switching between two heart medications, ticagrelor and clopidogrel, can help people with acute coronary syndrome after heart procedures while keeping them safe from bleeding.

  Recruiting Phase 4 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT04937699

• CT scan to check coronary bypass graft openness after CABG in ACS patients on aspirin alone versus aspirin plus ticagrelor

  This project will use CT scans to see if people who had coronary bypass surgery for acute coronary syndrome have better graft openness when taking aspirin plus ticagrelor (DAPT) compared with aspirin alone.

  Recruiting University Hospital, Linkoeping · Bergen and 5 other locations · NCT04783701

• Dual H. pylori eradication versus proton pump inhibitor to prevent gastrointestinal bleeding in heart-attack patients on dual antiplatelet therapy

  This trial tests whether a two-week vonoprazan-plus-amoxicillin H. pylori eradication regimen lowers gastrointestinal bleeding compared with standard PPI use in adults with acute coronary syndrome who are H. pylori–positive and on dual antiplatelet therapy after stenting.

  Recruiting at 26 sites Phase 4 Qilu Hospital of Shandong University · Bozhou, Anhui and 41 other locations · NCT04728516

• Combining Dabigatran and Ticagrelor for Patients with Atrial Fibrillation and Acute Coronary Syndrome Undergoing PCI

  This study is testing a new combination of two blood thinners, dabigatran and reduced-dose ticagrelor, to see if it works just as well as the usual triple therapy for patients with atrial fibrillation and heart issues who are having a procedure called PCI.

  Recruiting Phase 4 Medical University of Gdansk · Gdansk, Pomeranian Voivodeship · NCT04695106

• Optimal antithrombotic strategy for patients with atrial fibrillation undergoing PCI

  This study is testing whether a new blood-thinning treatment for patients with atrial fibrillation undergoing heart procedures is safer and just as effective as the traditional approach that includes more medications.

  Recruiting at 18 sites Phase 4 St. Antonius Hospital · Aalst and 19 other locations · NCT04436978

• Comparing a new medication to standard treatment for preventing stomach issues in heart patients on blood thinners

  This study is testing a new medication called tegoprazan to see if it can prevent stomach problems just as well as the standard treatment for heart patients who are taking blood thinners.

  Recruiting at 36 sites Phase 4 Asan Medical Center · Anyang and 44 other locations · NCT04416581

• Comparing Ticagrelor with Low-dose Aspirin to Regular Aspirin for Heart Patients

  This study is testing whether Ticagrelor with low-dose Aspirin is safer and more effective than Ticagrelor with regular-dose Aspirin for heart patients at high risk after a procedure to open blocked arteries.

  Recruiting Phase 4 Fu Wai Hospital, Beijing, China · Beijing, Beijing Municipality · NCT04240834

• Collecting blood samples from heart attack patients to identify new biomarkers

  This study is collecting blood samples from heart attack patients during routine procedures to see if they can find new markers that help us understand heart disease better.

  Recruiting at 2 sites Royal Brompton & Harefield NHS Foundation Trust · Harefield, Middlesex and 1 other locations · NCT04218344

• High-dose statin therapy for patients with acute coronary syndrome

  This study is testing if giving high doses of statins right away to patients with acute coronary syndrome can improve their heart health during and after their hospital stay.

  Recruiting Centro Cardiopatici Toscani · Prato · NCT04087200

• Identifying triggers and progression of heart failure

  This study looks at patients with heart failure to see what causes it and how it gets worse, while also testing if digoxin can help those whose heart failure is triggered by fast heartbeats.

  Recruiting University Hospital, Basel, Switzerland · Basel · NCT04000061

• Registry for patients undergoing angioplasty in Korea

  This study is collecting information from patients who have had angioplasty to help understand how well the treatment works in real life.

  Recruiting Yonsei University · Seoul · NCT03908463

• Evaluating patients with acute coronary syndrome and myocardial injury

  This study is collecting information from patients with acute coronary syndrome or heart injury to better understand their conditions and improve future care.

  Recruiting at 3 sites IRCCS Azienda Ospedaliero-Universitaria di Bologna · Bologna, Bologna and 2 other locations · NCT03883711

• Registry for evaluating care in acute coronary syndrome

  This study is creating a registry to track how well different treatments and devices work for people with acute coronary syndrome in real-life situations.

  Recruiting at 4 sites St. Antonius Hospital · Apeldoorn, Gelderland and 3 other locations · NCT03823547

• Evaluating frailty in elderly patients undergoing heart procedures

  This study looks at how frailty affects the recovery and outcomes of heart procedures in older patients aged 65 and up with coronary artery disease.

  Recruiting Medical University of Silesia · Zabrze, Upper Silesia · NCT03209414

• Registry of patients with coronary artery issues and platelet test results

  This study collects information from patients with coronary artery disease to see how well their blood-thinning medications work and to find the best treatment options for them.

  Recruiting Action, France · Paris · NCT02762162

• Investigating new cardiac biomarkers for diagnosing acute coronary syndrome

  This study is testing new blood markers to see if they can help doctors better diagnose acute coronary syndrome in patients who might be having a heart attack.

  Recruiting Universitätsklinikum Hamburg-Eppendorf · Hamburg · NCT02355457

• Revascularization options for adults with multivessel coronary disease and non-ST-elevation ACS

  This trial will test whether stenting (PCI) or bypass surgery (CABG) is better for adults who present with non-ST-elevation acute coronary syndrome and severe multivessel coronary artery disease.

  Recruiting at 9 sites American Heart of Poland · Chrzanów, Malopolska and 8 other locations · NCT01311323

• Survey of patients with acute coronary syndromes

  This study is looking to gather information from patients with heart problems like unstable angina and heart attacks in Eastern Europe to see how they are treated and how they do over time.

  Recruiting University of Bologna · Bologna, Emilia-Romagna · NCT01218776

NIH-funded research (7)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• A new behavioral program to boost activity after a heart event

  A new program uses friendly telephone coaching to help people recover after a heart attack by being more active and feeling more hopeful.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11370580

• AI screening to speed STEMI diagnosis in ED patients

  A Stanford-led project uses artificial intelligence to quickly identify STEMI among ED patients with acute coronary syndrome to reduce treatment delays and improve outcomes.

  NIH research Stanford University · Stanford, United States · NIH-11262229

• Helping people stay active after a heart attack

  This project is testing a new way to help people who have had a heart attack become more physically active using phone calls and positive thinking exercises.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11097385

• Improving heart attack diagnosis using artificial intelligence

  This study is working on using artificial intelligence to help emergency departments quickly and accurately identify heart attacks, especially for women and people of color who might not get diagnosed as fast, so everyone can receive the care they need within the first 10 minutes of arriving.

  NIH research Stanford University · Stanford, United States · NIH-10999429

• Coaching program to reduce depression and improve health after heart attacks

  This study is testing a friendly coaching program called Behavioral Activation for Health and Depression (BA-HD) to help heart patients who are also feeling depressed, by encouraging better habits like taking their medicine, being active, and eating well, and it will compare this program to regular care to see how well

  NIH research Miriam Hospital · Providence, United States · NIH-10904926

• How health insurance deductibles affect care for chest pain and heart conditions

  This study looks at how high deductible health insurance plans affect people with chest pain and heart issues, especially how costs might make them think twice about getting emergency care, and it aims to help improve healthcare policies for better patient outcomes.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-10903823

• A new approach to encourage physical activity after heart attacks

  This study is looking at how a friendly phone program can help heart patients feel better and get moving more after a heart event, making it easier for them to set and reach their personal activity goals.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-10873805

Related topics

Quick answers

How many Acute Coronary Syndrome clinical trials are recruiting right now?

70, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 32 countries. The most sites are in China (14 trials), South Korea (8 trials), Italy (8 trials), Netherlands (6 trials), United States (6 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 10, Phase 3: 4, Phase 2: 3, Phase 2/3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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