Identifying biomarkers to predict tuberculosis risk in kids and HIV patients
Official title: Identifying correlates of risk for future tuberculosis disease progression in children (INTREPID)
Funded at Stellenbosch University · NIH-11519035 · Data updated 2026-11-12
Researchers will study stored samples from young children and people with HIV to find biomarkers that signal who might progress to active TB and how they respond to treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stellenbosch University NIH-funded |
| Lab location | 1 site (Stellenbosch, SOUTH AFRICA) |
| Project start | May 5, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $243,814 |
| NIH project number | 3R01AI175235-04S1 |
| Project ID | NIH-11519035 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal participants include young children exposed to TB and individuals living with HIV, particularly those with recent Mtb exposure.
✕Less likely to help
Patients without Mtb exposure or without HIV coinfection may not directly benefit from these biomarkers.
What this research studies
This project will analyze existing samples from children and HIV-positive individuals to look for molecular signatures across genes, proteins, metabolites, and antibodies. By combining these data with information about HIV status and clinical factors, the team aims to identify the best indicators that TB preventive therapy might be most effective. The goal is to translate these findings into clinical tools that help clinicians decide when to start prevention and how to monitor treatment in real-world settings. The work will be conducted at Stellenbosch University with a focus on both U.S. and global applicability.
Why it matters
Potential benefit: If successful, clinicians could use the identified biomarkers to tailor TB prevention and treatment for children and HIV-positive patients, potentially reducing TB progression and severe disease.
How similar studies have gone: Past studies in TB biomarker research have identified promising signatures, but this project combines multi-omics for improved prediction in children and HIV-positive groups, which is a novel integration.
Where this research is happening
-
Stellenbosch University
Stellenbosch, South Africa Active
Researchers
- Principal investigator: Seddon, James Alexander — Stellenbosch University
- Study coordinator: Seddon, James Alexander
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.