Improving tuberculosis diagnosis in Swiss children

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to enhance the sensitivity of novel immunodiagnostic tests for detecting tuberculosis (TB) in children. It involves measuring various parameters in blood samples and comparing them with existing diagnostic standards for TB. The study will evaluate several new M. tuberculosis-specific antigens and cytokines, as well as perform NMR analysis to identify metabolomic signatures associated with TB infection and disease. The goal is to establish biomarkers that can effectively differentiate between TB infection and disease in pediatric patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* all children / adolescents \< 18 years of age undergoing evaluation for TB exposure, infection or disease.

Exclusion Criteria:

* children / adolescents with TB infection or disease who have already been started on anti-mycobacterial treatment, children who have been treated for TB previously.

Where it's running

• Kantonspital Aarau
  Aarau, Switzerland Recruiting
• Nina Vaezipour
  Basel, Switzerland Recruiting
• Ospedale Regionale di Bellinzona
  Bellinzona, Switzerland Recruiting
• Inselspital Bern
  Bern, Switzerland Recruiting
• Hôpital des enfants - HUG
  Geneva, Switzerland Recruiting
• Kinserspital Luzern
  Lucerne, Switzerland Recruiting

Study contacts

• Principal investigator: Nicole Ritz, Prof Dr med — Ukbb
• Study coordinator: Nina Vaezipour, Dr med
• Email: nina.vaezipour@ukbb.ch
• Phone: +41617042947

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.