Understanding how some patients develop chronic pain after knee replacement surgery.

Transition from Acute to Chronic Pain in Total Knee Arthroplasty Patients: Identifying Resilience and Vulnerability Profiles

['FUNDING_OTHER'] · RUSH UNIVERSITY MEDICAL CENTER · NIH-10593786

This study is looking at what helps some people avoid long-lasting pain after knee surgery, so if you're having a total knee replacement, your experiences and feelings could help us find ways to keep others from developing chronic pain.

Quick facts

Phase['FUNDING_OTHER']
Study typeNih_funding
SexAll
SponsorRUSH UNIVERSITY MEDICAL CENTER (nih funded)
Locations1 site (CHICAGO, UNITED STATES)
Trial IDNIH-10593786 on ClinicalTrials.gov

What this research studies

This research investigates the factors that influence whether patients experience a transition from acute pain to chronic pain following total knee arthroplasty. By identifying resilience and vulnerability profiles among patients, the study aims to understand the psychological and physiological factors that contribute to pain outcomes. Patients will be assessed through various evaluations and questionnaires to gather data on their pain experiences and coping mechanisms. The goal is to develop targeted interventions that can help prevent chronic pain in at-risk individuals.

Who could benefit from this research

Good fit: Ideal candidates for this research are individuals scheduled for total knee arthroplasty who are interested in understanding their pain management and recovery process.

Not a fit: Patients who have already undergone knee replacement surgery and are not experiencing acute pain may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to improved strategies for preventing chronic pain in patients undergoing knee replacement surgery.

How similar studies have performed: Other research has shown promise in identifying factors related to pain outcomes in surgical patients, suggesting that this approach could yield valuable insights.

Where this research is happening

CHICAGO, UNITED STATES

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.

View on NIH RePORTER →

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.