Understanding how some patients develop chronic pain after knee replacement surgery.
Official title: Transition from Acute to Chronic Pain in Total Knee Arthroplasty Patients: Identifying Resilience and Vulnerability Profiles
Funded at Rush University Medical Center · NIH-10593786 · Data updated 2026-11-12
This study is looking at what helps some people avoid long-lasting pain after knee surgery, so if you're having a total knee replacement, your experiences and feelings could help us find ways to keep others from developing chronic pain.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rush University Medical Center NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | April 1, 2022 |
| Project end | July 31, 2025 |
| Funding year | 2022 |
| Award (this year) | $2,694,707 |
| NIH project number | 3UM1NS112874-03S1 |
| Project ID | NIH-10593786 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals scheduled for total knee arthroplasty who are interested in understanding their pain management and recovery process.
✕Less likely to help
Patients who have already undergone knee replacement surgery and are not experiencing acute pain may not benefit from this research.
What this research studies
This research investigates the factors that influence whether patients experience a transition from acute pain to chronic pain following total knee arthroplasty. By identifying resilience and vulnerability profiles among patients, the study aims to understand the psychological and physiological factors that contribute to pain outcomes. Patients will be assessed through various evaluations and questionnaires to gather data on their pain experiences and coping mechanisms. The goal is to develop targeted interventions that can help prevent chronic pain in at-risk individuals.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing chronic pain in patients undergoing knee replacement surgery.
How similar studies have gone: Other research has shown promise in identifying factors related to pain outcomes in surgical patients, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Rush University Medical Center
Chicago, United States Active
Researchers
- Principal investigator: Burns, John W. — Rush University Medical Center
- Study coordinator: Burns, John W.
Related research
Other NIH-funded projects on the same topics.
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Reducing oxidative stress to help prevent chronic pain after knee surgery
This study is looking at whether taking an antioxidant before and during knee surgery can help reduce pain after the operation, and it's for people who are having total knee replacement surgery.
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This NIH grant studies why a small group of people aged 80+ keep memory skills as good as much younger people, hoping to understand how to protect memory as we age.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.