Oral vs IV Dexamethasone in Knee Replacement Recovery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective, single-center observational study follows patients undergoing primary total knee arthroplasty to see how routine dexamethasone given by mouth or IV influences early postoperative recovery. Outcomes include pain levels, functional mobility, knee range of motion, inflammatory markers, metabolic changes, opioid use, and nausea/vomiting. Allocation to oral or IV dexamethasone is determined by the surgeon’s standard practice, not by the study, so the analysis reflects real-world care. No experimental interventions or randomization are introduced, and all procedures adhere to existing perioperative protocols.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age between 50 and 80 years
* Diagnosis of primary knee osteoarthritis (primary gonarthrosis)
* Scheduled for elective primary total knee arthroplasty
* ASA physical status I or II
* Ability to ambulate independently (with or without assistive devices) preoperatively
* Ability to understand study procedures and complete pain and functional assessments
* Provision of written informed consent

Exclusion Criteria:

* Revision total knee arthroplasty
* History of knee joint infection
* Inflammatory arthritis (e.g., rheumatoid arthritis)
* Chronic systemic corticosteroid use
* Uncontrolled diabetes mellitus
* Known endocrine disorders affecting glucose metabolism
* Active infection at any site
* Known hypersensitivity to corticosteroids
* Severe hepatic, renal, or cardiac disease
* Neurological or musculoskeletal disorders affecting gait or balance
* Inability or unwillingness to comply with study procedures

Where it's running

• Sultangazi Haseki Training and Research Hospital
  Istanbul, Istanbul, Turkey (Türkiye) Recruiting

Study contacts

• Principal investigator: Mehmet Ersin, Associate Professor — Sultangazi Haseki Training and Research Hospital
• Study coordinator: Atahan Eryilmaz, Resident Physician
• Email: dratahaneryilmaz@gmail.com
• Phone: +90 552 609 9055

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.