Local infiltration analgesia vs quadruple nerve blocks for total knee replacement
Official title: Local Infiltration Analgesia Versus Quadruple Nerve Blocks in Total Knee Arthroplasty: a Randomized Controlled Trial.
Run by CMC Ambroise Paré · NCT07477730 · Data updated 2026-11-12
This study tests whether a surgical local infiltration analgesia approach can provide similar pain relief to quadruple nerve blocks after total knee arthroplasty.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 80 (estimated) |
| Sponsor | CMC Ambroise Paré Academic / other |
| Locations | 1 site (Toulouse, Haute-Garonne) |
| Status | Recruiting |
| Started | September 2, 2026 |
| Main results expected | March 3, 2028 |
| Study ends | May 2, 2028 |
| Registry record updated | September 14, 2026 |
| Trial ID | NCT07477730 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults undergoing primary total knee arthroplasty under general anesthesia, autonomous at home, and planned for home discharge.
✕Probably not a fit
Patients who have contraindications to regional anesthesia or who do not experience improved pain control with nerve blocks may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a single-center, randomized, open-label trial comparing two regional analgesia strategies used with multimodal pain control after total knee arthroplasty. One group receives the standard local infiltration analgesia, while the other receives nerve blocks of the femoral, sciatic, obturator, and lateral femoral cutaneous nerves. All participants get general anesthesia with standardized intraoperative medications and a postoperative regimen of acetaminophen and ketoprofen. Eligible patients are adults undergoing primary TKA, autonomous at home, and planned for discharge to home, with exclusions for preoperative opioid use and other contraindications. The aim is to determine which technique provides better analgesia while preserving motor function and enabling early mobilization.
Why it matters
Potential benefit: If the quadruple nerve blocks prove superior, patients may experience better pain control and faster recovery after knee replacement.
How similar studies have gone: Preliminary data in regional anesthesia suggest sensory-blocking nerve techniques can provide effective analgesia with minimal motor impairment, but results vary by technique.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients undergoing primary total knee arthroplasty under general anesthesia (laryngeal mask airway) * Fully autonomous at home * Planned discharge to home * Consent for participation * Affiliation to a social security system Exclusion Criteria: * Preoperative opioid use * Chronic pain syndrome * Valgus contraindicating sciatic nerve block * Contraindication to any drugs used in the protocol * Contraindication to laryngeal mask airway * Pregnant or breastfeeding women * Patients under protection of the adults (guardianship, curators or safeguard of justice)
Where it's running
-
Clinique Médipôle Garonne
Toulouse, Haute-Garonne, France Recruiting
Study contacts
- Study coordinator: Philippe MARTY, MD
- Email: philippemarty@hotmail.com
- Phone: 05 62 13 29 97
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.