Reducing oxidative stress to help prevent chronic pain after knee surgery
Official title: Reducing Perioperative Oxidative Stress to Prevent Postoperative Chronic Pain Following Total Knee Arthroplasty
Funded at Vanderbilt University Medical Center · NIH-10933522 · Data updated 2026-11-12
This study is looking at whether taking an antioxidant before and during knee surgery can help reduce pain after the operation, and it's for people who are having total knee replacement surgery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | September 30, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $949,178 |
| NIH project number | 5R01AG085287-02 |
| Project ID | NIH-10933522 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults scheduled for total knee arthroplasty due to osteoarthritis.
✕Less likely to help
Patients who are not undergoing total knee arthroplasty or those with conditions unrelated to oxidative stress may not benefit from this research.
What this research studies
This research investigates whether lowering oxidative stress before and during total knee arthroplasty (TKA) can lead to better long-term pain outcomes for patients. The study will involve a randomized trial where participants receive either an antioxidant treatment or a placebo prior to and during their surgery. Researchers will measure levels of oxidative stress and pain intensity at various points after the surgery to determine if the treatment makes a difference in recovery. The goal is to provide insights that could improve pain management strategies for TKA patients.
Why it matters
Potential benefit: If successful, this research could lead to improved pain relief and recovery for patients undergoing total knee arthroplasty.
How similar studies have gone: Previous research has indicated that oxidative stress may contribute to chronic pain, suggesting that this approach could be promising, although it is being tested in this specific context for the first time.
Where this research is happening
-
Vanderbilt University Medical Center
Nashville, United States Active
Researchers
- Principal investigator: Bruehl, Stephen — Vanderbilt University Medical Center
- Study coordinator: Bruehl, Stephen
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.