Clinical trial Recruiting at 2 sites Interventional Ages 18 and up

Teleprehabilitation program for knee replacement surgery

Official title: The Added Value of Multimodal Biopsychosocial Teleprehabilitation in People Undergoing Total Knee Arthroplasty: a Pilot/Feasibility Trial

Run by Universitair Ziekenhuis Brussel · NCT06565377 · Data updated 2026-11-12

This study is testing a new online program to help people getting knee replacement surgery prepare better and recover faster compared to regular pre-surgery advice.

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment40 (estimated)
SponsorUniversitair Ziekenhuis Brussel
Academic / other
Locations2 sites (Geel, Antwerpen and 1 other locations)
StatusRecruiting
StartedJuly 31, 2024
Main results expectedAugust 31, 2026
Study endsAugust 31, 2027
Registry record updatedJune 15, 2026
Trial IDNCT06565377 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are Dutch-speaking adults over 18 years old who are scheduled for elective primary total knee arthroplasty.

Probably not a fit

Patients with significant comorbidities, cognitive impairments, or those undergoing emergency knee surgeries may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the feasibility and acceptability of a multimodal biopsychosocial teleprehabilitation program for patients scheduled for total knee arthroplasty. It aims to prepare patients for surgery by providing comprehensive pre-surgical education and rehabilitation strategies through telehealth. The study will compare the effects of this teleprehabilitation approach against standard preoperative advice to assess its impact on patient outcomes. The focus is on enhancing patient readiness and recovery post-surgery.

Why it matters

Potential benefit: If successful, this approach could lead to improved surgical outcomes and faster recovery for patients undergoing knee replacement surgery.

How similar studies have gone: Other studies have shown promising results with teleprehabilitation approaches, indicating potential for success in this novel application.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* People scheduled for elective primary TKA at one of the participating hospitals;
* Being over 18 years old;
* Dutch speaking/reading

Exclusion Criteria:

* Doing activities that make them feel out of breath for 300 minutes or more per week on average;
* Orthopedic, neurological, cardiovascular or any other condition/comorbidity that leads to an overall contraindication for moderate physical activity;
* Cognitive impairment (≥11 on 6-item Cognitive Impairment Test and/or unable to understand the study instructions);
* Presence of uncontrolled inflammatory arthritides (e.g., rheumatoid arthritis, gout);
* Uncontrolled psychiatric disorders;
* Active cancer and/or active cancer treatment ((hormonal) maintenance therapy is allowed);
* People undergoing emergency (non-elective) TKA.

Where it's running

  • Ziekenhuis Geel
    Geel, Antwerpen, Belgium
    Recruiting
  • Universitair Ziekenhuis Brussel
    Brussels, Brussels Capital, Belgium
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

  • Mind mapping-based education to help after knee replacement

    A group of adults having total knee replacement will receive mind-mapping education in addition to standard care to see if it helps with pain, fear of movement, and readiness to leave the hospital.

    Recruiting Inonu University · Batman · NCT07885449

  • DoACs vs LMWH for blood flow after knee replacement

    This study tests whether rivaroxaban, apixaban, or LMWH work differently to support blood flow in the legs after total knee replacement in adults.

    Recruiting Military Hospital of Tunis · Tunis, Tunis Governorate · NCT07869615

  • Branched chain amino acids after knee replacement to help muscle

    This trial tests whether giving Livact after knee replacement helps preserve muscle and function in adults with sarcopenia.

    Recruiting at 2 sites Phase 4 Seoul National University Hospital · Seongnam-si, Gyeonggi-do and 2 other locations · NCT07634523

  • Cryotherapy to Cut Opioid Use After Knee Replacement

    This trial tests whether compressive cryotherapy with a Game Ready device can lower opioid use and improve recovery after total knee replacement in adults 60–80.

    Recruiting Hospital Italiano de Buenos Aires · Buenos Aires, Buenos Aires · NCT07630337

  • Early cognitive changes after same-day hip or knee replacement

    This study tests whether older adults (65 or older, 70 per description) who have same-day discharge after hip or knee replacement show changes in cognitive test performance from before surgery to the first day after surgery.

    Recruiting Odense University Hospital · Svendborg · NCT07598552

  • Preoperative Genicular Nerve Block for Knee Replacement

    This study tests whether giving a genicular nerve block before knee replacement can reduce pain after surgery and lower opioid use.

    Recruiting Helse Møre og Romsdal HF · Hjelset, Møre og Romsdal · NCT07589127

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.