Reducing opioid use before knee surgery

Developing and Testing an Opioid Taper Intervention Before Total Knee Arthroplasty

NIH-funded research University of Alabama at Birmingham · NIH-10896978

This study is looking at a new way to help people reduce their use of opioids before they have knee surgery, which can lead to less pain and a smoother recovery afterward.

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionUniversity of Alabama at Birmingham NIH-funded
Lab location1 site (Birmingham, United States)
Project IDNIH-10896978 on NIH RePORTER

What this research studies

This research focuses on developing a protocol to taper opioid use in patients before they undergo total knee arthroplasty, a common surgery for severe knee osteoarthritis. The study aims to create a structured approach to reduce opioid dependence, which can lead to better postoperative outcomes and less pain. By conducting a pilot randomized trial, the researchers will assess how feasible and effective this tapering intervention is for patients preparing for surgery. The goal is to improve recovery and rehabilitation experiences for these patients.

Who could benefit from this research

Good fit: Ideal candidates for this research are patients scheduled for total knee arthroplasty who are currently using opioids for pain management.

Not a fit: Patients who are not using opioids or those who are not candidates for total knee arthroplasty may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to improved pain management and recovery for patients undergoing total knee arthroplasty.

How similar studies have performed: While some small retrospective studies have suggested benefits of opioid tapering before surgery, this research aims to provide high-quality prospective data, making it a novel approach.

Where this research is happening

Birmingham, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-09 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.