Managing swelling after knee replacement surgery

Swelling Management after Total Knee Arthroplasty

['FUNDING_R21'] · UNIVERSITY OF COLORADO DENVER · NIH-10897974

This study is looking at a new adjustable compression garment to help reduce swelling after knee replacement surgery, which could make recovery easier and improve your overall healing.

Quick facts

Phase['FUNDING_R21']
Study typeNih_funding
SexAll
SponsorUNIVERSITY OF COLORADO DENVER (nih funded)
Locations1 site (Aurora, UNITED STATES)
Trial IDNIH-10897974 on ClinicalTrials.gov

What this research studies

This research investigates how to effectively manage swelling that occurs after total knee arthroplasty (TKA), a common surgery for patients with severe knee osteoarthritis. The study will evaluate a new type of adjustable compression garment that has shown promise in reducing swelling by 50% in preliminary tests. By focusing on the relationship between swelling and muscle activation, the research aims to improve rehabilitation outcomes and reduce long-term disability. Patients will be monitored to assess the garment's effectiveness on various recovery metrics.

Who could benefit from this research

Good fit: Ideal candidates for this research are individuals scheduled to undergo total knee arthroplasty due to end-stage osteoarthritis.

Not a fit: Patients who have already undergone knee replacement surgery or those with contraindications to compression garments may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to improved recovery and reduced long-term disability for patients undergoing knee replacement surgery.

How similar studies have performed: Preliminary studies have shown success with similar approaches, indicating potential for this method to be effective in a larger trial.

Where this research is happening

Aurora, UNITED STATES

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.

View on NIH RePORTER →

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.