Managing swelling after knee replacement surgery
Official title: Swelling Management after Total Knee Arthroplasty
Funded at University of Colorado Denver · NIH-10897974 · Data updated 2026-11-12
This study is looking at a new adjustable compression garment to help reduce swelling after knee replacement surgery, which could make recovery easier and improve your overall healing.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | August 2, 2023 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $150,002 |
| NIH project number | 5R21AR082101-02 |
| Project ID | NIH-10897974 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals scheduled to undergo total knee arthroplasty due to end-stage osteoarthritis.
✕Less likely to help
Patients who have already undergone knee replacement surgery or those with contraindications to compression garments may not benefit from this research.
What this research studies
This research investigates how to effectively manage swelling that occurs after total knee arthroplasty (TKA), a common surgery for patients with severe knee osteoarthritis. The study will evaluate a new type of adjustable compression garment that has shown promise in reducing swelling by 50% in preliminary tests. By focusing on the relationship between swelling and muscle activation, the research aims to improve rehabilitation outcomes and reduce long-term disability. Patients will be monitored to assess the garment's effectiveness on various recovery metrics.
Why it matters
Potential benefit: If successful, this research could lead to improved recovery and reduced long-term disability for patients undergoing knee replacement surgery.
How similar studies have gone: Preliminary studies have shown success with similar approaches, indicating potential for this method to be effective in a larger trial.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Bade, Michael J — University of Colorado Denver
- Study coordinator: Bade, Michael J
Related research
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-
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-
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This trial gives an antioxidant medicine around the time of knee replacement to help reduce long-term pain for people having total knee arthroplasty.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.