Comparing two regional anesthesia techniques for knee replacement
Official title: Comparison of the Effects of Ultrasound-Guided Adductor Canal Block With iPACK (Space Between the Popliteal Artery and the Posterior Knee Capsule) Block Combination and Suprainguinal Fascia Iliaca Block on Postoperative Pain and Stress Response in Patients Undergoing Total Knee Arthroplasty
Run by SB Istanbul Education and Research Hospital · NCT07092982 · Data updated 2026-11-12
This trial tests whether ultrasound-guided supra-inguinal fascia iliaca block or ultrasound-guided adductor canal block (with iPACK as part of the regimen) gives better pain control and less opioid use for adults having total knee replacement.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 75 Years |
| Sex | All |
| Enrollment | 52 (estimated) |
| Sponsor | SB Istanbul Education and Research Hospital Academic / other |
| Locations | 1 site (Istanbul) |
| Status | Recruiting |
| Started | August 4, 2025 |
| Main results expected | July 1, 2026 |
| Study ends | July 2026 |
| Registry record updated | April 6, 2026 |
| Trial ID | NCT07092982 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18–75 undergoing total knee arthroplasty with ASA I–III who can consent and have no contraindications to nerve blocks are ideal candidates.
✕Probably not a fit
Patients with coagulation disorders, active infection at the block site, pre-existing neurologic deficits, severe liver or renal failure, long-term analgesic use, or other contraindications to nerve block are unlikely to benefit or be eligible.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Adults scheduled for total knee arthroplasty will receive ultrasound-guided peripheral nerve blocks as part of their postoperative analgesia, using either a supra-inguinal fascia iliaca approach or an adductor canal approach, with an iPACK block used in the regimen. The trial will monitor postoperative pain scores, opioid consumption, early mobilization, and block-related complications. Eligible participants are adults 18–75 with ASA physical status I–III and without contraindications to regional anesthesia. Data will be used to compare pain control effectiveness and secondary outcomes such as nausea, vomiting, and length of stay.
Why it matters
Potential benefit: If successful, the preferred block could improve postoperative pain control, reduce opioid use, and speed recovery after knee replacement.
How similar studies have gone: Adductor canal plus iPACK techniques have shown benefit in total knee arthroplasty in prior work, while the use of supra-inguinal fascia iliaca block for this operation is less well established.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients undergoing total knee arthroplasty * Patients aged 18-75 * Patients with ASA I-II-III Exclusion Criteria: * Coagulation disorders * Allergy to local anesthetics * Liver and renal failure * Alcohol and drug addiction * Cognitive dysfunction that may prevent pain assessment * Systemic or needle insertion site infection * Analgesic use for more than 3 months * Patient refusal to participate in the study/refusal to consent * Presence of a hematoma, hernia, neoplasm, etc. in the area where the block will be performed * Pre-existing neurological deficit * Patients with contraindications to nerve block
Where it's running
-
SB Istanbul Education and Research Hospital
Istanbul, Turkey (Türkiye) Recruiting
Study contacts
- Study coordinator: Kubilay Ekinci, MD
- Email: kubilay.ekinci@sbu.edu.tr
- Phone: 0905062671972
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.