Condition

Total Knee Replacement clinical trials and research

• 16Clinical trials
• 11NIH research projects
• 8Countries

Newest Total Knee Replacement clinical trials

All recruiting trials (16)

• Suzetrigine for pain relief after knee replacement

  This trial tests whether suzetrigine can reduce opioid use after a total knee replacement compared with placebo.

  Recruiting Phase 3 Hospital for Special Surgery, New York · New York, New York · NCT07864896

• Femoral Component Alignment in Total Knee Replacement: Extramedullary vs Intramedullary Guidance

  This study tests whether an external (extramedullary) guide for placing the femoral component in knee replacement works as well as the traditional internal (intramedullary) guide.

  Recruiting I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio · Milan and 2 other locations · NCT07815080

• Physical therapy to improve gait and foot pressure after total knee replacement.

  This program will see if a structured physical therapy rehabilitation program helps women who had a unilateral total knee replacement (ages 40–70) walk more normally and balance weight better on their feet.

  Recruiting Jouf University · Sakakah · NCT07556003

• Dressing experiences and self-care after hip or knee replacement

  This observational study tests how patients manage dressings and wound care after hip or knee replacement within an ERAS pathway, to see how comfortable the dressings are and what education patients find helpful.

  Recruiting Bournemouth University · Bournemouth, Dorset and 1 other locations · NCT07471243

• Binaural beats to reduce pain and anxiety after hip or knee replacement

  This will try a 30-minute binaural beats audio session in the PACU to see if it lowers pain and anxiety for adults having same-day total hip or knee replacement.

  Recruiting University of Miami · Miami, Florida · NCT07437469

• Spinal versus general anesthesia for recovery after total knee replacement

  This will test whether spinal anesthesia or general anesthesia leads to better early postoperative recovery for adults who have had total knee replacement.

  Recruiting University Hospital, Strasbourg, France · Strasbourg · NCT07275983

• Robotic Mako cementless versus cemented total knee replacement

  This study will test whether robotic Mako cementless or cemented knee replacements work better for adults having a primary total knee replacement for osteoarthritis.

  Recruiting University College, London · London · NCT06929871

• Exploring movement differences in knee osteoarthritis and after knee replacement

  This study looks at how walking and movement are different in people with knee osteoarthritis, those who have had knee replacement surgery, and healthy individuals to see how these differences affect their ability to exercise and stay active.

  Recruiting University of Portsmouth · Portsmouth, Hampshire · NCT06829433

• Comparing two types of polyethylene in knee replacement surgery

  This study is testing which type of plastic used in knee replacement surgery helps patients feel better and move more easily after their operation.

  Recruiting University Hospital, Clermont-Ferrand · Clermont-Ferrand · NCT06676189

• Apixaban's effect on blood clotting in newly diagnosed multiple myeloma

  This test sees if apixaban lowers blood clotting more in people with newly diagnosed multiple myeloma than in people taking apixaban after knee replacement.

  Recruiting Centre Hospitalier Universitaire de Saint Etienne · Saint-Etienne · NCT06474182

• Comparing two methods for pain control after knee replacement surgery

  This study is testing two different pain control methods after knee replacement surgery to see which one helps patients feel better and recover faster.

  Recruiting at 2 sites Phase 2 Yale University · New Haven, Connecticut and 1 other locations · NCT05736549

• Fall prevention program for elderly after knee replacement

  This study tests if adding a fall prevention program to regular physical therapy can help older adults who have had knee replacement surgery stay safe from falls and improve their balance and movement.

  Recruiting Ministry of Health, Kuwait · Kuwait City · NCT05642260

• Evaluating the ORIGIN® CR knee prosthesis after total knee replacement

  This study is testing how well the ORIGIN® CR knee prosthesis works and if it helps people feel better and move easier after total knee replacement surgery over two years.

  Recruiting at 2 sites Symbios Orthopedie SA · Antwerp and 1 other locations · NCT05607966

• Comparing two pain management methods after knee surgery

  This study is testing two different pain management methods after knee surgery to see which one helps patients feel better and recover more effectively.

  Recruiting at 2 sites Phase 2 Yale University · New Haven, Connecticut and 1 other locations · NCT05279092

• Comparing cemented and uncemented knee replacements

  This study is testing whether knee replacements that use cement or those that don't lead to better results and satisfaction for patients over the long term.

  Recruiting NHS Greater Glasgow and Clyde · Glasgow, Scotland · NCT04677907

• Comparing different steroid administration methods after knee replacement surgery

  This study is testing whether giving steroids through an IV or directly into the knee helps people recover better after knee replacement surgery compared to not using steroids at all.

  Recruiting Phase 4 Ente Ospedaliero Cantonale, Bellinzona · Lugano · NCT04432012

NIH-funded research (11)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Self-powered knee implant load sensors to monitor total knee replacements

  A tiny, self-powered sensor system is being developed to monitor the loads on a total knee replacement so doctors can keep an eye on implant health from afar.

  NIH research State University of Ny,binghamton · Binghamton, United States · NIH-11412579

• Remote-based physical activity program for adults after total knee replacement

  A nationwide study tests a scalable, online program to help adults 12 months after knee replacement stay active and healthier without in-person visits.

  NIH research University of South Carolina at Columbia · Columbia, United States · NIH-11392375

• Self-powered knee implant that measures how your knee moves and bears weight inside the body

  A new knee replacement implant will quietly power and transmit measurements of your knee’s movement and the forces across the joint during daily life.

  NIH research Tennessee Technological University · Cookeville, United States · NIH-11380596

• How neighborhood and social factors influence when people get knee replacement

  This project looks at how neighborhood, healthcare access, and social circumstances affect when adults who need knee replacement actually receive surgery.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11252622

• Remote exercise program for people with knee replacements

  Different online program features will be tried to help adults who had a total knee replacement become more active.

  NIH research University of South Carolina at Columbia · Columbia, United States · NIH-11170525

• Investigating how social factors affect the timing of total knee replacement surgery

  This study looks at when people in the U.S. get knee replacement surgeries and how things like access to healthcare and living conditions affect that timing, so we can find ways to help more patients get the care they need when they need it.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11168650

• Improving Function and Pain After Total Knee Replacement Through Physical Activity and Weight Loss

  This program helps adults who have had total knee replacement surgery improve their movement and reduce pain by focusing on physical activity and healthy weight.

  NIH research University of South Carolina at Columbia · Columbia, United States · NIH-11144577

• Self-powered knee implant load monitor

  Building tiny battery-free sensors inside knee replacements to track how much force the implant experiences for people with knee replacements.

  NIH research State University of Ny,binghamton · Binghamton, United States · NIH-11090361

• Improving online exercise programs for adults with knee replacements

  This study is looking to improve an online exercise program called Energize! for adults who have had total knee replacement surgery, helping them get more active and stay healthy after their recovery.

  NIH research University of South Carolina at Columbia · Columbia, United States · NIH-10940877

• Understanding how pain sensitivity and genetics affect opioid use after knee surgery

  This study is looking at why some people need more pain medication than others after knee surgery, focusing on how their pain sensitivity and genetics might play a role, so we can better manage pain for everyone after surgery.

  NIH research Vanderbilt University · Nashville, UNITED STATES · NIH-10892842

• Improving function and reducing pain after knee replacement through physical activity and weight loss

  This study is looking at how a personalized weight loss program can help people recover better and feel healthier after knee replacement surgery, and it’s for those who want to improve their recovery and overall well-being.

  NIH research University of South Carolina at Columbia · Columbia, United States · NIH-10884200

Related topics

Quick answers

How many Total Knee Replacement clinical trials are recruiting right now?

16, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 8 countries. The most sites are in United Kingdom (4 trials), United States (4 trials), France (3 trials), Switzerland (1 trial), Belgium (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 2, Phase 4: 1, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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