Quadruple block plus adductor canal block for knee surgery pain
Official title: Comparison of the Benefit of Peripheral Nerve Quadri-block Versus Adductor Canal Block + Surgical Infiltration in Total Knee Arthroplasty
Run by GCS Ramsay Santé pour l'Enseignement et la Recherche · NCT06920186 · Data updated 2026-11-12
This study tests whether adding a quadruple nerve block to the standard adductor canal block reduces pain after total knee replacement.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | GCS Ramsay Santé pour l'Enseignement et la Recherche Academic / other |
| Locations | 2 sites (Quincy-sous-Sénart and 1 other locations) |
| Status | Recruiting |
| Started | May 4, 2026 |
| Main results expected | May 2027 |
| Study ends | June 2027 |
| Registry record updated | June 5, 2026 |
| Trial ID | NCT06920186 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults undergoing primary uni- or bilateral gonarthrosis requiring total knee arthroplasty who can provide informed consent.
✕Probably not a fit
Patients who do not respond to regional blocks or have contraindications to regional anesthesia may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Adults undergoing total knee arthroplasty are randomized to receive the standard adductor canal block with infiltration or an enhanced quadruple sensory block. The quadruple block includes the lateral femoral cutaneous nerve block, IPACK for posterior knee sensation, and obturator nerve block, aiming to spare motor function while improving analgesia. The trial focuses on analgesic efficacy and safety of the combined approach in the perioperative period. No phase information is provided.
Why it matters
Potential benefit: If successful, patients could experience better pain control with potentially less motor impairment after knee replacement.
How similar studies have gone: Prior regional anesthesia approaches show promise, but this quadruple-block strategy is relatively novel and its efficacy is not yet proven.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult male or female * Patient with signed consent to participate in the study, * Patient with uni or bilateral primary gonarthrosis * Indication for total knee arthroplasty. Exclusion Criteria: * History of knee fracture, arthroplasty or osteotomy * Known or unknown contraindication to ALR or locoregional anesthesia products * Neurological disease, stroke sequelae * Mental deficiency or any other reason that may hinder understanding or strict application of the protocol * Patient not affiliated to the French social security system * Patient under court protection, guardianship or curatorship * Pregnant or potentially pregnant women (women of childbearing age without effective contraception) * Patient already included in another therapeutic study protocol
Where it's running
-
Hôpital Privé Claude Galien
Quincy-sous-Sénart, France Recruiting -
Clinique des Côtes du Rhône
Roussillon, France Not yet recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.