Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Quadruple block plus adductor canal block for knee surgery pain

Official title: Comparison of the Benefit of Peripheral Nerve Quadri-block Versus Adductor Canal Block + Surgical Infiltration in Total Knee Arthroplasty

Run by GCS Ramsay Santé pour l'Enseignement et la Recherche · NCT06920186 · Data updated 2026-11-12

This study tests whether adding a quadruple nerve block to the standard adductor canal block reduces pain after total knee replacement.

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment100 (estimated)
SponsorGCS Ramsay Santé pour l'Enseignement et la Recherche
Academic / other
Locations2 sites (Quincy-sous-Sénart and 1 other locations)
StatusRecruiting
StartedMay 4, 2026
Main results expectedMay 2027
Study endsJune 2027
Registry record updatedJune 5, 2026
Trial IDNCT06920186 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults undergoing primary uni- or bilateral gonarthrosis requiring total knee arthroplasty who can provide informed consent.

Probably not a fit

Patients who do not respond to regional blocks or have contraindications to regional anesthesia may not benefit.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults undergoing total knee arthroplasty are randomized to receive the standard adductor canal block with infiltration or an enhanced quadruple sensory block. The quadruple block includes the lateral femoral cutaneous nerve block, IPACK for posterior knee sensation, and obturator nerve block, aiming to spare motor function while improving analgesia. The trial focuses on analgesic efficacy and safety of the combined approach in the perioperative period. No phase information is provided.

Why it matters

Potential benefit: If successful, patients could experience better pain control with potentially less motor impairment after knee replacement.

How similar studies have gone: Prior regional anesthesia approaches show promise, but this quadruple-block strategy is relatively novel and its efficacy is not yet proven.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Adult male or female
* Patient with signed consent to participate in the study,
* Patient with uni or bilateral primary gonarthrosis
* Indication for total knee arthroplasty.

Exclusion Criteria:

* History of knee fracture, arthroplasty or osteotomy
* Known or unknown contraindication to ALR or locoregional anesthesia products
* Neurological disease, stroke sequelae
* Mental deficiency or any other reason that may hinder understanding or strict application of the protocol
* Patient not affiliated to the French social security system
* Patient under court protection, guardianship or curatorship
* Pregnant or potentially pregnant women (women of childbearing age without effective contraception)
* Patient already included in another therapeutic study protocol

Where it's running

  • Hôpital Privé Claude Galien
    Quincy-sous-Sénart, France
    Recruiting
  • Clinique des Côtes du Rhône
    Roussillon, France
    Not yet recruiting

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.