How bone density and joint loads affect implant migration after knee replacement
Official title: How bone mineral density and joint loads affect implant migration after total knee arthroplasty
Funded at Hospital for Special Surgery · NIH-11433151 · Data updated 2026-11-12
A knee replacement project explores how bone density and how the knee is loaded relate to early implant movement that could lead to loosening.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Hospital for Special Surgery NIH-funded |
| Lab location | 1 site (New York, UNITED STATES) |
| Project start | September 3, 2026 |
| Project end | June 30, 2031 |
| Funding year | 2026 |
| Award (this year) | $639,896 |
| NIH project number | 1R01AR088362-01 |
| Project ID | NIH-11433151 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults who have undergone total knee arthroplasty and whose implant migration or loosening risk is of interest to the study.
✕Less likely to help
Some patients with low migration risk or those not undergoing imaging follow-up may not benefit directly.
What this research studies
This project at Hospital for Special Surgery uses CT-based radiostereometric analysis to track how tibial baseplates move over time after knee replacement. It aims to identify early signs that predict loosening by looking at patient-specific bone strength and joint loads. By analyzing CT scans and movement patterns, researchers hope to understand how to prevent migration and improve implant longevity. The study could lead to personalized strategies to reduce loosening risk and instability after surgery.
Why it matters
Potential benefit: If successful, patients may experience fewer cases of knee implant loosening and better long-term joint function.
How similar studies have gone: Prior studies have shown that early migration can predict loosening in some implants, but this project seeks to define early markers more precisely.
Where this research is happening
-
Hospital for Special Surgery
New York, United States Active
Researchers
- Principal investigator: Quevedo Gonzalez, Fernando Jose — Hospital for Special Surgery
- Study coordinator: Quevedo Gonzalez, Fernando Jose
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.