Optimizing preoperative nutrition and fasting for total knee replacement
Effect of ERAS-Based Preoperative Nutrition Education and Fasting Protocol on Postoperative Hydration Status and Nausea-Vomiting in Patients Undergoing Total Knee Arthroplasty
This trial will test whether an ERAS-based preoperative nutrition education and fasting plan helps people having elective total knee replacement stay better hydrated and have less nausea and vomiting after surgery.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 72 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Acibadem University Academic / other |
| Locations | 1 site (Istanbul, Istanbul) |
| Trial ID | NCT07336160 on ClinicalTrials.gov |
What this trial studies
This randomized controlled trial will compare an ERAS-based preoperative nutrition education and fasting protocol to standard preoperative care in adults undergoing elective total knee arthroplasty. The intervention provides specific guidance on food and clear-liquid timing in the 24 hours before surgery and structured hydration and education based on ERAS guidelines. Participants will be randomly assigned at Acıbadem Altunizade Hospital and outcomes will include postoperative hydration status and the incidence of nausea and vomiting during the immediate postoperative period. The trial enrolls adults able to consent who are expected to remain hospitalized at least 48 hours after surgery.
Who should consider this trial
Good fit: Adults aged 18 or older scheduled for elective total knee arthroplasty who can provide informed consent and are expected to stay in hospital at least 48 hours are ideal candidates.
Not a fit: Patients with chronic conditions requiring fluid restriction, acute preoperative dehydration, significant cognitive impairment, or those discharged early or transferred to intensive care are unlikely to benefit from the protocol.
Why it matters
Potential benefit: If successful, this approach could reduce postoperative dehydration and nausea/vomiting, improving comfort and recovery after total knee replacement.
How similar studies have performed: Shortened preoperative fasting and ERAS-style nutrition guidance have shown benefits in other surgical populations, although direct evidence specifically in total knee arthroplasty is limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Inclusion Criteria: * Adults aged 18 years and older. * Patients scheduled for elective total knee arthroplasty. * Patients expected to be hospitalized for at least 48 hours postoperatively. * Ability to communicate verbally and provide informed consent. * Patients with adequate cognitive and neurological capacity to understand study procedures. Exclusion Criteria: * Presence of any chronic disease requiring fluid restriction. * Diagnosed cognitive impairment or psychiatric disorders affecting comprehension (e.g., Alzheimer's disease, dementia, psychotic disorders). * Acute conditions causing dehydration in the preoperative period (e.g., vomiting, diarrhea, excessive fluid loss). * Intraoperative complications requiring intensive care unit admission. * Postoperative follow-up shorter than 48 hours due to early discharge or transfer to another clinic.
Where this trial is running
Istanbul, Istanbul
- Acıbadem Health Group Atakent Hospital — Istanbul, Istanbul, Turkey (Türkiye) (Recruiting)
Study contacts
- Principal investigator: Nermin Ocaktan, PhD — Acıbadem Mehmet Ali Aydınlar University
- Study coordinator: Nermin Ocaktan, PhD
- Email: nermin.ocaktan@acibadem.edu.tr
- Phone: +905337373306
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.