BiFeS and adductor canal block for pain after knee replacement
Official title: A Comparison of the Effects of Biceps Femoris Short Head Block and Adductor Canal Block in Total Knee Arthroplasty on Postoperative Analgesia Using Multimodal Analgesia Methods
Run by Kayseri City Hospital · NCT07577869 · Data updated 2026-11-12
This study tests whether adding a BiFeS block and adductor canal block to spinal anesthesia reduces opioid use and improves pain control after total knee arthroplasty.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 80 Years |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | Kayseri City Hospital Government |
| Locations | 1 site (Kayseri, Kocasinan) |
| Status | Recruiting |
| Started | June 2, 2026 |
| Main results expected | June 2, 2027 |
| Study ends | July 2, 2027 |
| Registry record updated | June 12, 2026 |
| Trial ID | NCT07577869 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18-80 with ASA I–III undergoing elective unilateral total knee arthroplasty and eligible for spinal anesthesia.
✕Probably not a fit
Patients who do not experience a meaningful reduction in pain or opioid use with the blocks may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
In this single-center randomized trial, 60 adults undergoing unilateral total knee arthroplasty under spinal anesthesia are assigned to receive either BiFeS block plus adductor canal block before surgery in addition to standard analgesia, or spinal anesthesia with standard analgesia alone. The primary outcome is total morphine consumption in the first 24 postoperative hours. Secondary outcomes include postoperative pain scores and analgesic requirements. All patients receive multimodal analgesia and morphine PCA, with rescue fentanyl as needed. The study aims to determine if peripheral nerve blocks can lessen opioid needs and improve recovery after knee replacement.
Why it matters
Potential benefit: If successful, patients may experience less opioid use and better pain control after knee replacement.
How similar studies have gone: Peripheral nerve blocks are increasingly used in multimodal analgesia, with some evidence of opioid-sparing effects in knee surgery, but exact BiFeS and adductor canal block combinations require further validation.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients aged 18 and older * ASA I-III * Patients scheduled for elective unilateral knee replacement * Eligibility for and consent to spinal anesthesia Exclusion Criteria: * History of allergy or anaphylaxis to local anesthetics, animal gelatin, or chlorhexidine * Bleeding diathesis/inability to discontinue anticoagulants * Infection (at the injection site/sepsis) * Neurological disorders or cognitive impairment affecting pain perception * Pregnancy, breastfeeding * Patients under 18 years of age
Where it's running
-
Kayseri City Hospital
Kayseri, Kocasinan, Turkey (Türkiye) Recruiting
Study contacts
- Study coordinator: Omer Kayar, Medicinae Doctor
- Email: dr.omer.kayar@hotmail.com
- Phone: +90 531 578 90 37
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.